Induced Signal Transduction by Interaction between Nano-sized polymer Aggregates and Plasma Membrane of Cells
| Project/Area Number |
22510120
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Nanomaterials/Nanobioscience
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| Research Institution | Osaka University |
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Principal Investigator |
NISHIKAWA Takehiro 大阪大学, 大学院・情報科学研究科, 特別科学研究員 (40281836)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | ナノバイオ / ナノ材料 / 生体機能利用 / ナノ粒子 / 細胞膜 / エンドサイトーシス / カベオラ / 細胞内シグナル伝達 / 両親媒性ポリシロキサン / 一酸化窒素合成酵素 |
|---|
| Research Abstract |
n our research project supported by Grant-in-Aid for Scientific Research (C) (22510120), we studied how the expression level and phosphorylation of endothelial nitric oxide synthase (eNOS) are influenced when nanoparticles of amphiphilic polymer are endocytosed into vascular endothelial cells. We experimentally demonstrated that cellular uptake of the synthetic nanoparticles of polysiloxane can be processed assignals and result in the enhanced cellular responses (nitric oxide release). 交付決定額
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Report
(4 results)
Research Products
(26 results)
