Development of microinterface devices for long-term observation of mouse brain
| Project/Area Number |
22510124
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Microdevices/Nanodevices
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| Research Institution | The University of Tokyo |
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Principal Investigator |
ICHIKI Takanori 東京大学, 大学院・工学系研究科, 准教授 (20277362)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | マイクロバイオシステム / 脳計測 / in vivo計測 / バイオデバイス / イメージング / マウス / 2光子顕微鏡 / マイクロバルブ |
|---|
| Research Abstract |
The observation of neural cells in the intact brain of a living animal is one of the most significant challenges in neuroscience. Two-photon laser scanning microscopy (2PLSM) enables the cellular imaging of brain tissue up to a depth of several hundred micrometers and the stimulation of a single synapse of neurons by the photolytic release of caged glutamate, and is thus a powerful tool in neuroscience. However, in the case of observing the intact brain of a living animal, one should drill a hole in the skull and remove the dura to observe deep inside the brain tissue and introduce caged glutamate. Thus, bacterial infection and the loss of brain fluid prevent long-term observation over several weeks. Therefore, we have developed an implantable microscale brain interface device for controlling the concentration of chemicals and enabling the long-term observation of cells in the tissues of living animals by applying microfluidic device technoloy.
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Report
(4 results)
Research Products
(52 results)
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[Presentation] Shape-memory polymer microvalves2012
Author(s)
H. Takehara, K. Uto, M. Ebara, T. Aoyagiand T. Ichiki
Organizer
The 16th Int. Conf. on Miniaturized Systems for Chemistry and Life Sciences (Micro-TAS2012)
Place of Presentation
Okinawa, Japan
Related Report
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[Presentation] Shape-memory polymer microvalves2012
Author(s)
H. Takehara, K. Uto, M. Ebara, T. Aoyagi and T. Ichiki
Organizer
16h International Conference on Miniaturized Chemical and Biochemical Analysis Systems
Place of Presentation
Okinawa Convention Center, Okinawa
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