| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
In this study, we aimed to identify the regulatory pathway a novel life-duration related gene, rabgap. We clarified that the product interacts with Gα2 and Gα9 in a GTP-dependent manner by pull-down assay. Biochemical analysis revealed that the RabGAP gene product regulates cAMP synthesis which is a driving force for Dictyostelium discoideum development. Furtheremore, it was found that arachidonic acid synthesis pathway also contributes the cAMP synthesis. We also suggested that RabGAP participates in Lysosomal pathway and regulates cell proliferation probably via Gα9.
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