Base excision repair of DNA in chromatin structure
| Project/Area Number |
22510206
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Genome biology
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| Research Institution | Iwate Medical University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Keywords | DNA修復 / クロマチン構造 / クロマチンリモデリング / メチル化DNA |
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| Research Abstract |
Genomic DNA is continuously suffered from modification including oxidation and hydrolysis. DNA repair is crucial system for maintaining genetic information, however, chromatin structure is obstacle for repair enzym es to access damage sites. We found a novel protein that interacts with XRCC1, a non-enzymatic DNA repair protein. These proteins localized to insoluble nuclear fraction and critical for chromosomal DNA repair.
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Report
(4 results)
Research Products
(5 results)
