Classification of functionally unknown genes based on their transcriptional regulation
| Project/Area Number |
22510208
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Genome biology
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
SHINKAI Akeo 独立行政法人理化学研究所, 機能解析第1研究チーム, チームリーダー (10391989)
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| Co-Investigator(Renkei-kenkyūsha) |
AGARI Yoshihiro 独立行政法人理化学研究所, 機能解析第1研究チーム, 特別研究員 (50469889)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 遺伝子発現調節 / X線結晶構造 / 機能発見 / 高度好熱菌 / Thermus thermophilus / 蛋白質 / TetRファミリー / 転写因子 / 機能ゲノム科学 / 転写制御 / 機能未知遺伝子 / mRNA |
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| Research Abstract |
In order to find a clue to identify the function of the functionally unknown genes, we categorized them based on their transcriptional regulation, using Thermus thermophilus HB8 as a model organism. Genetic information in DNA is transcribed to mRNA, which is often regulated by protein called transcription factor. In many cases, the transcription reaction of several genes sharing similar cellular functions is simultaneously regulated by a transcription factor. Here, we investigated the function of four novel transcription factors, and identified six functionally unknown genes which were transcriptionally regulated together with functionally identified genes. This study may lead to identify the function of the functionally unknown genes.
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Report
(5 results)
Research Products
(28 results)
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[Presentation] Structural and functional genomics of a model organism Thermus thermophilus HB8: toward functional discovery of functionally unknown proteins2011
Author(s)
Shinkai A, Bessho Y, Agari Y, Iino H, Fukui K, Kitamura A, Sakamoto K, Kim K, Masui R, Yokoyama S, Kuramitsu S
Organizer
International Conference on Structural Genomics
Place of Presentation
Chestnut Conference Centre、トロント、カナダ
Year and Date
2011-05-13
Related Report
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