| Project/Area Number |
22510214
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical genome science
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
IWASAKI Naoko 東京女子医科大学, 医学部, 准教授 (70203370)
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| Co-Investigator(Kenkyū-buntansha) |
NAKANISHI Toshio 東京女子医科大学, 医学部, 教授 (90120013)
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| Co-Investigator(Renkei-kenkyūsha) |
OGATA Makiko 東京女子医科大学, 医学部, 講師 (10233404)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 2 型糖尿病 / MODY / 創薬 / 次世代シークエンサー / iPS / β細胞 / ミトコンドリア / SNP / 糖尿病 / ｉＰＳ細胞 / KCNJ15 / LSS / RCNJ15 / 2型糖尿病 / ゲノム / 単一遺伝 / ミトコンドリア内膜pH / 感受性多型 |
|---|
| Research Abstract |
For type 2 diabetes susceptibility genes, we have identified two genes, LSS and KCNJ15 on chromosome 21, under the peak of LOD curve we had reported. We showed that glucose levels were improved by suppressing the expression of each gene by administration of siRNA in diabetic animal, indicating that LSS and KCNJ15 could be the therapeutic targets for type 2 diabetes. We also found two causative genes by using next generation sequencers in a large MODY family
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