Identification and functional analysis of the allele-specific DNA-binding factors that recognize type 2 diabetes susceptibility SNPs using nanobeads technology
| Project/Area Number |
22510216
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical genome science
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| Research Institution | Research Institute, International Medical Center of Japan |
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Principal Investigator |
HIRAMOTO Masaki 独立行政法人国立国際医療研究センター, 代謝疾患研究部, 室長 (70297828)
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| Co-Investigator(Renkei-kenkyūsha) |
YASUDA Kazuki 独立行政法人国立国際医療研究センター, 代謝疾患研究部, 部長 (80311611)
UDAGAWA Haruhide 独立行政法人国立国際医療研究センター, 代謝疾患研究部, 研究員 (50533882)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 2 型糖尿病 / 一塩基多型 / ナノビーズ / ゲノム / 糖尿病 / 疾患感受性遺伝子 |
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| Research Abstract |
Single nucleotide polymorphisms (SNPs) in KCNQ1 gene locus confer susceptibility to type 2 diabetes. In this study, we identified the proteins that bind this locus in allele-specific manner using nanobeads technology, and showed that the identified proteins can participate in the regulation of gene expressions. This means that SNPs in KCNQ1 gene modulate the affinity of the locus for DNA-binding proteins, which possibly change gene expressions and consequently increase risk of type 2 diabetes.
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Report
(4 results)
Research Products
(5 results)
