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Identification and functional analysis of the allele-specific DNA-binding factors that recognize type 2 diabetes susceptibility SNPs using nanobeads technology

Research Project

Project/Area Number 22510216
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Medical genome science
Research InstitutionResearch Institute, International Medical Center of Japan

Principal Investigator

HIRAMOTO Masaki  独立行政法人国立国際医療研究センター, 代謝疾患研究部, 室長 (70297828)

Co-Investigator(Renkei-kenkyūsha) YASUDA Kazuki  独立行政法人国立国際医療研究センター, 代謝疾患研究部, 部長 (80311611)
UDAGAWA Haruhide  独立行政法人国立国際医療研究センター, 代謝疾患研究部, 研究員 (50533882)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords2 型糖尿病 / 一塩基多型 / ナノビーズ / ゲノム / 糖尿病 / 疾患感受性遺伝子
Research Abstract

Single nucleotide polymorphisms (SNPs) in KCNQ1 gene locus confer susceptibility to type 2 diabetes. In this study, we identified the proteins that bind this locus in allele-specific manner using nanobeads technology, and showed that the identified proteins can participate in the regulation of gene expressions. This means that SNPs in KCNQ1 gene modulate the affinity of the locus for DNA-binding proteins, which possibly change gene expressions and consequently increase risk of type 2 diabetes.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (5 results)

All 2013 2012 2011

All Presentation (5 results)

  • [Presentation] Type 2 Diabetes-Associated SNPs within KCNQ1 Gene Modulate the Affinity of the Locus for DNA-Binding Factors.2013

    • Author(s)
      Hiramoto M, Udagawa H, Watanabe A, Kawaguchi M, Nishimura W, Nammo T, Yasuda K
    • Organizer
      73^<rd> Scientific Sessions, American Diabetes Association
    • Place of Presentation
      Chicago, IL, USA
    • Year and Date
      2013-06-24
    • Related Report
      2012 Final Research Report
  • [Presentation] KCNQ1遺伝子イントロンのSNP領域においてアリル特異的に結合する因子の単離・同定・解析2012

    • Author(s)
      平本正樹, 宇田川陽秀, 渡邉淳, 上番 増喬, 川口美穂, 石橋奈緒子, 南茂隆 生, 西村渉, 安田和基
    • Organizer
      第55回日本糖尿病学会年次学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2012-05-18
    • Related Report
      2012 Final Research Report
  • [Presentation] KCNQ1遺伝子イントロンのSNP領域においてアリル特異的に結合する因子の単離・同定・解析2012

    • Author(s)
      平本正樹
    • Organizer
      日本糖尿病学会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2012-05-18
    • Related Report
      2012 Annual Research Report
  • [Presentation] KCNQ1 遺伝子イントロンにおける2 型糖尿病感受性SNP の機能解析2011

    • Author(s)
      平本正樹, 宇田川陽秀, 渡邉淳, 上番 増喬, 川口美穂, 南茂隆生, 西村渉, 安田和基
    • Organizer
      日本人類遺伝学会第56回大会
    • Place of Presentation
      千葉
    • Year and Date
      2011-11-11
    • Related Report
      2012 Final Research Report
  • [Presentation] KCNQ1遺伝子イントロンにおける2型糖尿病感受性SNPの機能解析2011

    • Author(s)
      平本正樹
    • Organizer
      日本人類遺伝学会
    • Place of Presentation
      幕張メッセ(千葉県)
    • Year and Date
      2011-11-11
    • Related Report
      2011 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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