Exploring of regulatory substances ofTSP-1, an endogenous inhibitor of angiogenesis
Project/Area Number |
22510236
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Living organism molecular science
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Research Institution | Kagoshima University |
Principal Investigator |
IWAGAWA Tetsuo 鹿児島大学, 大学院・医歯学総合研究科, 客員研究員 (10041245)
|
Co-Investigator(Kenkyū-buntansha) |
FURUKAWA Tatsuhiko 鹿児島大学, 大学院・医歯学総合研究科, 教授 (40219100)
下茂 徹朗 鹿児島大学, 理工学研究科, 准教授 (80041565)
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Co-Investigator(Renkei-kenkyūsha) |
SHIMO Tetsuro 鹿児島大学, 大学院・理工学研究科, 准教授 (80041565)
|
Project Period (FY) |
2010 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | TSP-1 / 血管新生抑制 / 天然物 / 海洋天然物 / 血管新生阻害 / 海綿 |
Research Abstract |
Thrombospondin-1(TSP-1) is an anti-angiogenic protein. We and others previously found that some anticancer drugs could inducethe expression of TSP-1. Novel substances that can induce or suppression TSP-1 expression without toxicity could be new therapeutic tools for treatment of cancer and some vascular diseases. We found TSP-1 inducing activities in specific fractions of marine sponge extracts. Furthermore, we investigated bioactive compounds from several marine animals, affording some interesting compounds including ten new ones.
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Report
(4 results)
Research Products
(152 results)
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[Journal Article] Molecular basis for the expression of major vault protein induced by hyperosmotic stress in SW620 human colon cancer cells2013
Author(s)
Tajitsu Y, Ikeda R, Nishizawa Y, Mataki H, Che XF, Sumizawa T, Nitta M, YamaguchT, Yamamoto M, Tabata S, Akiyama S, Yamada K, Furukawa T, Takeda Y
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Peer Reviewed
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[Journal Article] VEGF expression is augmented by hypoxia-induced PGIS in human fibroblasts2013
Author(s)
Wang J, Ikeda R, Che X-f, Ooyama A, Yamamoto M, Furukawa T, Hasui K, Zheng Cl, Tajitsu Y, Oka T, Tabata S, Nishizawa Y, Eizuru Y, Akiyama S
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[Journal Article] Molecular basis for the regulation of hypoxia-inducible factor-1α levels by 2-deoxy-D-ribose2013
Author(s)
Ikeda R, Tabata S, Tajitsu Y, Nishizawa Y, Minami K, Furukawa T, Yamamoto M, Shinsato Y, Akiyama S, Yamada K , Takeda Y.
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[Journal Article] Snail modulates cell metabolism in MDCK cells2013
Author(s)
Haraguchi M, Indo HP, Iwasaki Y, Iwashita Y, Fukushige T, Majima HJ, Izumo K, Horiuchi M, Kanekura T, Furukawa T, Ozawa M
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Journal Title
Biochem Biophys Res Commun
Volume: 432
Pages: 618-625
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Peer Reviewed
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[Journal Article] Thymidine phosphorylase enhances reactive oxygen species generation and interleukin-8 expression in human cancer cells2012
Author(s)
Tabata S, Ikeda R, Yamamoto M, Furukawa T, Kuramoto T, Takeda Y, Yamada K, Haraguchi M, Nishioka Y, Sone S, Akiyama S
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Journal Title
Oncology Reports
Volume: 28
Pages: 895-902
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Peer Reviewed
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[Journal Article] Akiyama S, Thymidine phosphorylase enhances reactive oxygen species generation and interleukin-8 expression in human cancer cells2012
Author(s)
Tabata S, Ikeda R, Yamamoto M, Furukawa T, Kuramoto T, Takeda Y, Yamada K, Haraguchi M, Nishioka Y, Sone S
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Journal Title
Oncol Rep
Volume: 28
Pages: 895-902
DOI
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[Journal Article] Cytotoxic eunicellin-type diterpenes from the soft coral liphyton viscudium2011
Author(s)
Iwagawa T, Kusatsu T, Tsuha K, Hamada T, Okamura H, Furukawa T, Akiyama S, Doe M, Morimoto Y, Iwase F, Takemurae K
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Journal Title
Heterocycles
Volume: 83
Pages: 2149-2155
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[Journal Article] Novel cytotoxic isolated from Jamaican Hyptis verticillata jacq induces apoptosis and overcomes multidrug resistance2011
Author(s)
White Y, Hamada T, Yoshimitsu M, Nakashima M, Hachiman M, Kozako T, Matsushita K, Uozumi K, Suzuki S, Kofune H, Furukawa T, Arima N
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Journal Title
Anticancer Res
Volume: 31
Pages: 251-4257
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Peer Reviewed
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[Journal Article] Cytotoxic Isomalabaricane Derivatives and a Monocyclic Triterpene Glycoside from the Sponge Rhabdastrella globostellata2010
Author(s)
Hirashima M, Tsuda K, Hamada T, Okamura H, Furukawa T, Akiyama S, Tajitsu Y, Ikeda R, Komatsu M, Doe M, Morimoto Y, Shiro M, van Soest RW, Takemura K, Iwagawa T
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Journal Title
J. Nat. Prod.
Volume: 73
Pages: 1512-1518
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Peer Reviewed
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[Journal Article] p53 Plays an Important Role in Cell Fate Determination after Exposure to Microcystin-LR2010
Author(s)
Takumi S, Komatsu M, Furukawa T, Ikeda R, Sumizawa T, Akenaga H, Maeda Y, AoyamaK, Arizono K, Ando S, Takeuchi T
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Journal Title
Environmental Health Perspectives
Volume: 118
Pages: 1292-1298
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Peer Reviewed
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[Journal Article] The role of thymidine phosphorylase in the induction of early growth response protein-1 and thrombospondin-1 by 5-fluorouracil in human cancer carcinoma cells2010
Author(s)
Matsushita S, Ikeda R, Nishizawa Y, Che XF, Furukawa T, Miyadera K, Tabata S, Ushiyama M, Tajitsu Y, Yamamoto M, Takeda Y, Minami K, Mataki H, Kanzaki T, Yamada K, Kanekura T, Akiyama S
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Journal Title
Int J Oncol.
Volume: 36
Pages: 1193-200
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[Presentation] Expression of CNT1 and RRM1 are involved in gemcitabine resistant of pancreatic cancer cells2013
Author(s)
Minami K, Yamamoto M, Ikeda R, Komatsu M, Kawahara K, Shinsato Y, Tabata S, Yamada K, Akiyama S, Takeda Y, Furukawa T
Organizer
19th International Charles Heidelberger Symposium on Cancer Research
Place of Presentation
19th International Charles Heidelberger Symposium on Cancer Research
Year and Date
2013-02-16
Related Report
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[Presentation] 5-AZa-2-deoxy cytidine (5-Aza-CdR) enhance the sensitivity of 5-fluorouracil (5-FU) in KB3-1 human carcinoma cells2013
Author(s)
Nishizawa Y, Ikeda R, Tabata S, Tajitsu Y, Kawahara K, Yamamoto M, Shinsato Y, Minami K, Akiyama S, Furukawa T, Takeda Y
Organizer
19th International Charles Heidelberger Symposium on Cancer Research
Place of Presentation
Kagoshima
Year and Date
2013-02-13
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[Presentation] The expression of CNT1 and RRM1 are related to the gemcitabine resistance in the pancreatic gemcitabine resistant cells2010
Author(s)
Minami K, Furukawa T, Komatsu M, Ikeda R, Yamamoto M, Tabata S, Shinsato Y, Che X-F, Takeda Y, Akiyama S, Yamada K
Organizer
The 20th Japan-Korea Joint Seminar on Pharmacology
Place of Presentation
Kagoshima
Year and Date
2010-11-17
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