| Project/Area Number |
22510236
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Living organism molecular science
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| Research Institution | Kagoshima University |
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Principal Investigator |
IWAGAWA Tetsuo 鹿児島大学, 大学院・医歯学総合研究科, 客員研究員 (10041245)
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| Co-Investigator(Kenkyū-buntansha) |
FURUKAWA Tatsuhiko 鹿児島大学, 大学院・医歯学総合研究科, 教授 (40219100)
下茂 徹朗 鹿児島大学, 理工学研究科, 准教授 (80041565)
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| Co-Investigator(Renkei-kenkyūsha) |
SHIMO Tetsuro 鹿児島大学, 大学院・理工学研究科, 准教授 (80041565)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | TSP-1 / 血管新生抑制 / 天然物 / 海洋天然物 / 血管新生阻害 / 海綿 |
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| Research Abstract |
Thrombospondin-1(TSP-1) is an anti-angiogenic protein. We and others previously found that some anticancer drugs could inducethe expression of TSP-1. Novel substances that can induce or suppression TSP-1 expression without toxicity could be new therapeutic tools for treatment of cancer and some vascular diseases. We found TSP-1 inducing activities in specific fractions of marine sponge extracts. Furthermore, we investigated bioactive compounds from several marine animals, affording some interesting compounds including ten new ones.
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