DEVELOPMENT OF NEW FUNCTIONAL MOLECULES BY POLYCYCLIC ALKALOIDS

• Project/Area Number: 22510239
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Living organism molecular science
• Research Institution: Hoshi University
• Principal Investigator: MORITA Hiroshi 星薬科大学, 薬学部, 教授 (70220069)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 植物 / 生理活性 / 天然物 / アルカロイド / 創薬リード化合物 / 機能性分子 / 熱帯未利用植物資源 / 未利用植物資源

Research Abstract

Plants remain to this day one of the most important sources of biological active compounds and continue to provide drug discovery seeds. During our search for active ingredients from medicinal plants, we have isolated anti-malarial polycyclic alkaloids and limonoids with anti-lipid-droplets accumulation activity as new drug discovery seeds and evaluated their activities.

Research Products

• [Journal Article] Ceramicine B, A Limonoid with Anti-Lipid Droplets Accumulation Activity from Chisocheton ceramicus (2014)
  • Author(s): Chin Piow Wong, Toshio Kaneda, A. Hamid A. Hadi, and Hiroshi Morita
  • Journal Title: J Nat Med. Volume: (in press) Issue: 1 Pages: 22-30
  • DOI: 10.1007/s11418-013-0755-2
  • Peer Reviewed
• [Journal Article] New Limonoids from Chisocheton ceramicus (2012)
  • Author(s): Wong Chin Piow, Misae Shimada, Alfarius Eko Nugroho, Yusuke Hirasawa, Toshio Kaneda, A. Hamid A. Hadi, Shirota Osamu and Hiroshi Morita, Ceramicines J-L
  • Journal Title: J. Nat. Med. Volume: 66 Issue: 3 Pages: 566-570
  • DOI: 10.1007/s11418-011-0616-9
  • Peer Reviewed
• [Journal Article] New Tricyclic Alkaloids, Cassiarins G, H, J, and K from Leaves of Cassia siamea (2012)
  • Author(s): Jun Deguchi, Tomoe Hirahara, Yusuke Hirasawa, Wiwied Ekasari, Aty Widyawaruyanti, Osamu Shirota, Motoo Shiro, and Hiroshi Morita
  • Journal Title: Chemical and Pharmaceutical Bulletin Volume: 60 Issue: 2 Pages: 219-222
  • DOI: 10.1248/cpb.60.219
  • NAID: 130001852399
  • ISSN: 0009-2363, 1347-5223
  • Peer Reviewed
• [Journal Article] Absolute Configurational Elucidation of Monoterpene Indole Alkaloids by Circular Dichroism (2012)
  • Author(s): Alfarius Eko Nugroho
  • Journal Title: Heterocycles Volume: 84 Issue: 1 Pages: 101-113
  • DOI: 10.3987/rev-11-sr(p)2
  • Peer Reviewed
• [Journal Article] Alsmaphorazines C - E, Indole Alkaloids from Alstonia pneumatophora (2012)
  • Author(s): Koichiro Koyama
  • Journal Title: Tetrahedron Volume: 68 Issue: 5 Pages: 1502-1506
  • DOI: 10.1016/j.tet.2011.12.014
  • Peer Reviewed
• [Journal Article] Naucline, a new pyrano-indolo-quinolizidinone alkaloid from the bark of Nauclea officinalis (2012)
  • Author(s): Liew Sook Yee
  • Journal Title: Molecules Volume: 17 Issue: 4 Pages: 4028-4036
  • DOI: 10.3390/molecules17044028
  • Peer Reviewed
• [Journal Article] Neonaucline, a New Indole Alkaloid from the Leaves of Ochreinauclea maingayii (Hook. f.) Ridsd. (Rubiaceae) (2012)
  • Author(s): Mat Ropi Mukhtar
  • Journal Title: Molecules Volume: 17 Issue: 1 Pages: 267-274
  • DOI: 10.3390/molecules17010267
  • Peer Reviewed
• [Journal Article] Antiplasmodial Indole Alkaloids from Leuconotis griffithii (2012)
  • Author(s): Alfarius E. Nugroho
  • Journal Title: J. Nat. Med. Volume: 66 Issue: 2 Pages: 350-353
  • DOI: 10.1007/s11418-011-0574-2
  • Peer Reviewed
• [Journal Article] Vasorelaxant effect of isoquinoline derivatives from two species of Popowia perakensis and Phaeanthus crassipetalus on rat aortic artery (2012)
  • Author(s): Kazumasa Zaima
  • Journal Title: J. Nat. Med. Volume: 66 Issue: 3 Pages: 421-427
  • DOI: 10.1007/s11418-011-0600-4
  • Peer Reviewed
• [Journal Article] Leucomidines A – C, novel alkaloids from Leuconotis griffithii (2012)
  • Author(s): Midori Motegi
  • Journal Title: Tetrahedron Lett. Volume: 53 Issue: 10 Pages: 1227-1230
  • DOI: 10.1016/j.tetlet.2011.12.116
  • Peer Reviewed
• [Journal Article] Alstiphyllanines I - O, Ajmaline Type Alkaloids from Alstonia macrophylla showing Vasorelaxant Activity (2012)
  • Author(s): Hiroko Arai
  • Journal Title: Bioorg. Med. Chem. Volume: 20 Issue: 11 Pages: 3454-3459
  • DOI: 10.1016/j.bmc.2012.04.013
  • Peer Reviewed
• [Journal Article] Lycobelines A - C, Novel C16N2-type Lycopodium Alkaloids from Huperzia goebelii (2012)
  • Author(s): Yusuke Hirasawa
  • Journal Title: Tetrahedron Lett. Volume: 53 Issue: 31 Pages: 3971-3973
  • DOI: 10.1016/j.tetlet.2012.05.080
  • Peer Reviewed
• [Journal Article] Biomimetic synthesis of chrobisamone A from Cassia siamea (2012)
  • Author(s): Yuichiro Tomizawa
  • Journal Title: Heterocycles Volume: 86 Issue: 2 Pages: 1597-1601
  • DOI: 10.3987/com-12-s(n)111
  • Peer Reviewed
• [Journal Article] New Indole Alkaloids from Alstonia macrophylla (2012)
  • Author(s): Jun Deguchi
  • Journal Title: Heterocycles Volume: 86 Issue: 2 Pages: 1603-1610
  • DOI: 10.3987/com-12-s(n)112
  • Peer Reviewed
• [Journal Article] New Aspidofractinine and Aspidospermatan Indole Alkaloids from the roots of Kopsia singapurensis (2012)
  • Author(s): Kartini Ahmad
  • Journal Title: Heterocycles Volume: 86 Issue: 2 Pages: 1611-1619
  • DOI: 10.3987/com-12-s(n)113
  • Peer Reviewed
• [Journal Article] Ceramicines E-I, New Limonoids from Chisocheton ceramicus (2011)
  • Author(s): Wong Chin Piow, Misae Shimada, Yuta Nagakura Alfarius Eko Nugruho, Yusuke Hirasawa, Toshio Kaneda, Khalijah Awang, A. Hamid A. Hadi, Khalit Mohamad, Motoo Shiro, and Hiroshi Morita
  • Journal Title: Chemical and Pharmaceutical Bulletin Volume: 59 Issue: 3 Pages: 407-411
  • DOI: 10.1248/cpb.59.407
  • NAID: 130000648955
  • ISSN: 0009-2363, 1347-5223
  • Peer Reviewed
• [Journal Article] Total Synthesis of Cassiarin F, A Novel Tetracyclic Alkaloid from the Flowers of Cassia siamea (2011)
  • Author(s): Jun Deguchi, Tomoe Hirahara, Shiori Oshimi, Yusuke Hirasawa, Wiwied Ekasari, Osamu Shirota, Toshio Honda, and Hiroshi Morita
  • Journal Title: Org. Lett. Volume: 13 Issue: 16 Pages: 4344-4347
  • DOI: 10.1021/ol201674a
  • Peer Reviewed
• [Journal Article] Total Synthesis of Cassiarin F, A Novel Tetracyclic Alkaloid from the Flowers of Cassia siamea (2011)
  • Author(s): Jun Deguchi
  • Journal Title: Org.Lett. Volume: 13 Pages: 4344-4347
  • Peer Reviewed
• [Journal Article] Inhibitors of Nitric Oxide Production from Stemona javanica (2011)
  • Author(s): Takahiro Hosoya
  • Journal Title: Planta Medica Volume: 77 Issue: 03 Pages: 256-258
  • DOI: 10.1055/s-0030-1250383
  • Peer Reviewed
• [Journal Article] New Antiplasmodial Indole Alkaloids from Hunteria zeylanica (2011)
  • Author(s): Alfarius E.Nugroho
  • Journal Title: Bioorg.Med.Chem.Lett. Volume: 21 Issue: 11 Pages: 3417-3419
  • DOI: 10.1016/j.bmcl.2011.03.104
  • Peer Reviewed
• [Journal Article] Bisleuconothine A, an Eburnane-Aspidosperma Bisindole Alkaloid from Leuconotis griffithii (2010)
  • Author(s): Yusuke Hirasawa
  • Journal Title: Bioorg.Med.Chem.Lett. Volume: 20 Pages: 2021-2024
  • Peer Reviewed
• [Journal Article] Bisnicalaterines B and C, Atropoisomeric Bisindole Alkaloids from Hunteria zeylanica, showing Vasorelaxant Activity (2010)
  • Author(s): Yusuke Hirasawa
  • Journal Title: J.Org.Chem. Volume: 75 Pages: 4218-4223
  • Peer Reviewed
• [Journal Article] Alsmaphorazines A and B, Novel Indole Alkaloids from Alstonia pneumatophora (2010)
  • Author(s): Koichiro Koyama
  • Journal Title: Org.Lett. Volume: 12 Pages: 4188-4191
  • Peer Reviewed
• [Presentation] Cassia siamea および C. spectabilis に含有される抗 マラリア活性 アルカロイドの構造と合成 (2012)
  • Author(s): 出口潤,平原朋恵,石川登希夫,押見史 織 , 平澤祐介 ,本多利雄,代田修, Wiwied Ekasari,森田博史
  • Organizer: 第54回天然有機化合物討論会
  • Place of Presentation: 東京
• [Presentation] Ceramicines 類の脂肪蓄積抑 制作用とその構造活性相関 (2012)
  • Author(s): Chin Piow Wong, 出口潤 ,Alfarius Eko Nugroho, 平澤祐介 , 金田利夫 ,A. Hamid A. Hadi,森田博史
  • Organizer: 第19回天然薬物の開発と応用シンポジウム
  • Place of Presentation: 大阪
• [Presentation] Cassia siamea および C. spectabilis に含有される抗マラリア活性アルカロイドの構造と合成 (2012)
  • Author(s): 出口潤
  • Organizer: 第54回天然有機化合物討論会
  • Place of Presentation: 東京
• [Presentation] Ceramicines類の脂肪蓄積抑制作用とその構造活性相関 (2012)
  • Author(s): Chin Piow Wong
  • Organizer: 第19回天然薬物の開発と応用シンポジウム
  • Place of Presentation: 大阪
• [Presentation] Polycyclic Alkaloids and Cyclic Peptides from Medicinal Plants (2012)
  • Author(s): 森田博史
  • Organizer: 8th International Symposium on Chromatography of Natural Products
  • Place of Presentation: Poland
  • Invited
• [Presentation] Alstonia pneumatophoraおよびA.angustiloba由来の新規多環性インドールアルカロイドの構造研究 (2011)
  • Author(s): 小山晃一郎
  • Organizer: 第53回天然有機化合物討論会
  • Place of Presentation: 大阪国際交流センター
  • Year and Date: 2011-09-27
• [Presentation] マレーシア産Tabernaemontana dichotomaより単離したインドールアルカロイドの構造と血管平滑筋弛緩作用およびラットにおける降圧作用 (2011)
  • Author(s): 在間一将
  • Organizer: 第53回天然有機化合物討論会
  • Place of Presentation: 大阪国際交流センター
  • Year and Date: 2011-09-27
• [Presentation] Alstonia pneumatophora および A. angustiloba 由来の新規多環性インドールア ルカロイドの構造研究 (2011)
  • Author(s): 小山晃一郎,平澤祐介,金田利夫, Alfarius E. Nugroho ,細谷孝博,在間一将, Teh Chin Hoe , Kit-Lam Chan , 森田博史
  • Organizer: 第53回天然有機化 合物討論会
  • Place of Presentation: 大阪
• [Presentation] マレーシア産 Tabernaemontana dichotoma より単離 したインドールアルカロイドの構造と血管 平滑筋弛緩作用およびラットにおける降圧 作用 (2011)
  • Author(s): 在間一将古賀生美,岩沢信秀,Intan Safinar Ismail,Nordin Hj Lajis,細谷孝 博,平澤祐介,金田利夫,森田博史
  • Organizer: 第53回天然有機化合物討論会
  • Place of Presentation: 大阪
• [Presentation] マレーシア産Hunteria zeylanicaおよびLeuconotis griffithiiより単離した新規ビスインドールアルカロイドの構造と生物活性 (2010)
  • Author(s): Nugroho Alfarius Eko
  • Organizer: 第52回天然有機化合物討論会
  • Place of Presentation: 静岡グランシップ
  • Year and Date: 2010-10-01
• [Presentation] マレーシア産 Hunteria zeylanica および Leuconotis griffithii より単離した新規インドールアルカロイド の構造と生物活性 (2010)
  • Author(s): Alfarius Eko Nugroho,平澤祐介, 細谷孝博, 在間一将, Khalijah Awang,A. Hamid A. Hadi, 森田博史
  • Organizer: 第52回天然有機化合物討論会
  • Place of Presentation: 静岡
• [Remarks]
  • URL: http://polaris.hoshi.ac.jp/kyoshitsu/shouyaku/shouyaku.html
• [Remarks] 星薬科大学 生薬学教室 研究業績
  • URL: http://polaris.hoshi.ac.jp/kyoshitsu/shouyaku/shouyaku.html