| Project/Area Number |
22510241
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Living organism molecular science
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| Research Institution | Mukogawa Women's University |
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Principal Investigator |
OKU Hisae 武庫川女子大学, 薬学部, 助教 (90281518)
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| Co-Investigator(Kenkyū-buntansha) |
ISHIGURO Kyoko 武庫川女子大学, 薬学部, 教授 (70151363)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | かゆみ治療薬 / アッセイ法 / 天然資源 / 抗かゆみ / 病態モデル / ストレス / アレルギー / かゆみ |
|---|
| Research Abstract |
We established the efficient a model mouse and assay system for searching antipruriticsubstances from natural source for the therapeutic drug of serious itches such as atopicdermatitis. This method monitors the frequency of scratching behavior of the hen egg-whitelysozyme (HEL)-sensitized mouse (= chronic itching model) which exposed restraint stress.HEL-sensitized ddY mouse, in contrast to ddY mouse, have shown worsened the itchiness bystress like humans' atopic dermatitis case. For the search of the protein itch-related factor, weperformed proteome analysis. We screened the antipruritic activity of several natural sourcesand found new seeds and isolated the successively active substance.
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