Approach toward chemical synthesis of highly branched glycans of glycoconjugate
| Project/Area Number |
22510243
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Living organism molecular science
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
ISHIWATA Akihiro 独立行政法人理化学研究所, 伊藤細胞制御化学研究室, 専任研究員 (70342748)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 糖鎖合成 / オリゴ糖 / 立体選択的合成 / グリコシル化 / 収斂的合成 / 複合糖質糖鎖 / 多分岐糖鎖 / グリコシル化反応 |
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| Research Abstract |
Long-distance intramolecular aglycon delivery (IAD) was conducted to construct 1.2-cis glycosidic linkages whose stereoselective synthesis is one of the most difficult. The convergent strategy toward tetrabranched docosa- and hentriaconta-saccharide arabinan from Mycobacterial arabinan and the strategy for construction of highly branched structure have been studied. IAD method has been improved to achieve the syntheses of core structure of N-glycan and antifreeze glycan fragment from Upis ceramboides. The concentration effect on various factors of accelerated O-glycosylation when the reaction solvent was frozen has been studied.
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Report
(4 results)
Research Products
(54 results)
