| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
Biaryl compounds constitute a class of compounds employed in manyresearch fields. Therefore, the development of flexible synthetic methods for these compounds continuesto be an active area of research. The most common method for the preparation of biaryl compounds isthe transition-metal-catalyzed cross-coupling reaction between aryl halides and aryl metal reagents. Thesuccess of this powerful method, however, essentially depends upon the availability of the two couplingpartners. In this study, we developed a new synthetic approach to biaryl compounds from easilyprepared acyclic building blocks. The direct construction of aromatic rings using theRCEM/RCM/elimination sequence provides unique products without the formation of inseparable regioisomers.
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