Development of New Synthetic Methods for Biaryl Compounds Using Ring-Closing Metathesis
| Project/Area Number |
22550029
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Organic chemistry
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| Research Institution | Chiba University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | メタセシス / 閉環 / グラブス触媒 / 芳香族化合物 / ビアリール化合物 / オレフィンメタセシス / ビアリール / エンインメタセシス / ルテニウム |
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| Research Abstract |
Biaryl compounds constitute a class of compounds employed in manyresearch fields. Therefore, the development of flexible synthetic methods for these compounds continuesto be an active area of research. The most common method for the preparation of biaryl compounds isthe transition-metal-catalyzed cross-coupling reaction between aryl halides and aryl metal reagents. Thesuccess of this powerful method, however, essentially depends upon the availability of the two couplingpartners. In this study, we developed a new synthetic approach to biaryl compounds from easilyprepared acyclic building blocks. The direct construction of aromatic rings using theRCEM/RCM/elimination sequence provides unique products without the formation of inseparable regioisomers.
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Report
(4 results)
Research Products
(23 results)
