| Project/Area Number |
22550032
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Organic chemistry
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| Research Institution | Shizuoka University |
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Principal Investigator |
YODA Hidemi 静岡大学, 工学部, 教授 (20201072)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TAKAHASHI Masaki 静岡大学, 工学部, 准教授 (30313935)
SENGOKU Tetsuya 静岡大学, 工学部, 助教 (70451680)
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| Co-Investigator(Renkei-kenkyūsha) |
ASANO Naoki 北陸大学, 薬学部, 教授 (50121265)
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| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
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| Keywords | 複素環 / アルカロイド / ポリヒドロキシ / 立体異性体 |
|---|
| Research Abstract |
Recently a new series of hyacinthacines were isolated from bluebells and grape hyacinths by Asano et al. These compounds strongly inhibit various glycosidases in a reversible and competitive manner. While many total syntheses of hyacinthacine A series have been recently completed by several groups, the synthesis of hyacinthacine B and C series, however, has not been achieved to date. The central feature of this report is to describe the details of the first and expeditious route for the stereoselective construction of hyacinthacine B1, B2, C2, and C3 starting from (S)-2-pyrrolidone-5-carboxylic acid.
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