Synthetic Study of Ciguatoxin and Brevisin Based on Intramolecular Allylation
Project/Area Number |
22550036
|
Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Organic chemistry
|
Research Institution | Okayama University |
Principal Investigator |
KADOTA Isao 岡山大学, 大学院・自然科学研究科, 教授 (30250666)
|
Project Period (FY) |
2010 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | 合成有機化学 / 天然有機化合物 / ポリ環状エーテル / 海洋産天然物 / 全合成 / シガトキシン / 分子内アリル化 / 閉環メタセシス / グラブス触媒 / アリルスズ / グラプス触媒 |
Research Abstract |
In recent years there has been an explosion of interest in biologically active natural products of marine origin. Due to their structural novelty and toxicity, polycyclic ethers isolated from marine algae are particularly attractive targets for synthetic chemists. Since further biological studies are hampered by the limited availability from nature, chemical synthesis has been the sole realistic way to obtain sufficient amounts of the polycyclic ethers. In this study, convergent synthesis of polycyclic ethers via the intramolecular allyaltion and ring-closing metathesis were examined.
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Report
(4 results)
Research Products
(49 results)
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[Presentation] 門田 功2012
Author(s)
門田 功
Organizer
静岡大学理学部化学セミナー
Place of Presentation
静岡
Year and Date
2012-09-26
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