Total syntheses and reaction developments on the basis of axial-rich sugars
Project/Area Number |
22550047
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Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Organic chemistry
|
Research Institution | Kwansei Gakuin University |
Principal Investigator |
|
Project Period (FY) |
2010 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2012: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
|
Keywords | 合成有機化学 / 天然物合成 / アキシアル・リッチ糖 / エラジタンニン / 化学合成 / 3、6位架橋糖 / グリコシル化反応 / 立体選択的 / 有機化学 / 糖質 / ポリフェノール |
Research Abstract |
Utilizing the unique property of sugar derivatives, which conformation were locked into the axial-rich conformation, we developed (1) synthesis of ellagitannins and (2) stereoselective glycosylation reactions. In the research for (1), new synthetic routes for the axial-rich ellagitannins were developed to increase the lead in the aria of ellagitannin synthesis. For (2), highly α-selective glycosylations were developed by applying the sugars locked to the axial-rich conformations.
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Report
(4 results)
Research Products
(60 results)
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[Presentation] Totalsynthesis of praecoxin B2012
Author(s)
Hirokane, T.; Naoki, M.; Asakura, N.; Mitamura, T.; Yamada, H
Organizer
26thInternational Conference on Polyphenols
Place of Presentation
Firenche, Italy,poster,Awarded a poster prize
Year and Date
2012-07-23
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