Model Studies of Nickel Enzymes Included in Carbon Fixation Processes in Nature
| Project/Area Number |
22550059
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Inorganic chemistry
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | ニッケル酵素 / アセチル CoA合成酵素 / メチル CoM還元酵素 / チオラート / 炭素固定 / メタン生成 / アセチルCoA合成酵素 / メチルCoM還元酵素 / COデヒドロゲナーゼ / メタン菌 |
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| Research Abstract |
Nickel complexes modeling acetyl CoA synthase (ACS) and methylCoM reductase (MCR) were synthesized in order to investigate their structures and reactions wereto obtain clues to the unrevealed reaction mechanisms. Synthesis of a series of dinuclear nickelcomplexes having tetra-anionic diamido-dithiolate ligand mbpa modeling the plausibleintermediates of the catalytic reaction was achieved. As for MCR model complexes, the nickel(II)cyclams coordinated by methyl CoM sulfonate as an inactive form model and the nickel(I) cyclamsmodeling the active reduced state were synthesized.
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Report
(4 results)
Research Products
(53 results)
