| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
FRET is defined as an excited-state energy interaction between two fluorophores in which excited donor energy is transferred to an acceptor part without any photon-emission. In this study, some new FRET-based fluorescent chemosensors for metal ions were synthesized. For example, excited at 325 nm corresponding to the absorption of pyrene unit of 2-aminotryptanthrin-pyrene derivative (T2NH-PnP), emission at 600 nm from 2-aminotryptanthrin unit is observed, indicating that intramolecular FRET occurs in T2NH-PnP (FRET-on). However, when Hg^2+ or Cu^2+ is added to a solution of T2NH-PnP, the fluorescence of 2-aminotryptanthrin is dramatically quenched whereas that of pyrene is revived (FRET-off).
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