Development of HPLC separation system of bio-based highly hydrophilic compounds with ultrahigh separation efficiencies.
| Project/Area Number |
22550074
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Analytical chemistry
|
|---|
| Research Institution | Kyoto Institute of Technology |
|---|
Principal Investigator |
IKEGAMI Tohru 京都工芸繊維大学, 工芸科学研究科, 准教授 (20301252)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
|---|
| Keywords | HPLC / シリカモノリス / 重合修飾 / 高親水性化合物 / 高性能分離 / ＨＰＬＣ |
|---|
| Research Abstract |
Characterization method for hydrophilic interaction chromatographic stationary phases, based on hydrophilicity and selectivity for partial structure of analytes was developed. Using radical polymerization, functionalization method of monolithic silica columns was established. We could increase hydrophilic retention of highly polar compounds, by controlling monomer concentration of polymerization process. Significantly higher hydrophilicity and higher separation efficiency compared to commercially available HPLC columns were realized.
|
Report
(4 results)
Research Products
(28 results)
-
-
-
-
[Journal Article] Chromatographic characterization of hydrophilic interaction liquid chromatography stationary phases: Hydrophilicity, charge effects, structural selectivity, and separation efficiency2011
Author(s)
Kawachi, Yuusuke; Ikegami, Tohru; Takubo, Hirotaka; Ikegami, Yuka; Miyamoto, Masatoshi; Tanaka, Nobuo
-
Journal Title
Journal of Chromatography, A
Volume: 1218(35)
Issue: 35
Pages: 5903-5919
DOI
Related Report
Peer Reviewed
-
[Journal Article] Monolithic silica rod columns for high-efficiency reversed-phase liquid chromatography2011
Author(s)
Miyazaki, Shota; Takahashi, Masakazu; Ohira, Masayoshi; Terashima, Hiroyuki; Morisato, Kei; Nakanishi, Kazuki; Ikegami, Tohru; Miyabe, Kanji; Tanaka, Nobuo
-
Journal Title
Journal of Chromatography, A
Volume: 1218(15)
Issue: 15
Pages: 1988-1994
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Book] Monolithic Silicas in Separation Science2011
Author(s)
Takeshi Hara, Kosuke Miyamoto, Satoshi Makino, Shohei Miwa, Tohru Ikegami, Masayoshi Ohira, Nobuo Tanaka
Publisher
High-speed and high-efficiency separations by utilizing monolithic silica capillary columns.
Related Report
-
-
