Characterization of small organic molecules with threshold-energy dissociation mass spectrometry
| Project/Area Number |
22550090
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Analytical chemistry
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
NAKAMURA Takemichi 独立行政法人理化学研究所, 物質構造解析チーム, 専任研究員 (10360611)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 閾値エネルギー解離 / タンデム質量分析法 / 環状ペプチド化合物 / 構造解析 / モバイルプロトン / イオン移動度分析 / エネルギー分解質量分析 / 異性体識別 / 質量分析 / フラグメンテーション / 中性種脱離 / 異性化 / イオンモビリティー分析 / プロダクトイオン / イオンモビリティー / エネルギー分解 |
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| Research Abstract |
The basic concept and framework of threshold-energy dissociation mass spectrometry have been applied to various tandem mass spectrometers including quadrupole-type instruments. Analysis of fragmentation behavior of some organic molecules and threshold-energies allowed us to establish the basis for the exploitation of the method for identification of small molecules including isomers. An integrated analytical strategy including threshold dissociation and ion mobility tandem mass spectrometry was shown to be promising for characterization of isomeric ions and fragmentation networks.
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Report
(4 results)
Research Products
(17 results)
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[Journal Article] Novel angiotensin I-converting enzyme inhibitory peptides found in a thermolysin-treated elastin with antihypertensive activity2012
Author(s)
Sato, Y., Toyoda, T., Shimizu-Ibuka, A., Tamura, T., Kobayashi-Hattori, K., Nakamura, T., Arai, S., Mura, K.
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Journal Title
Bioscience, Biotechnology, and Biochemistry
Volume: 76
Pages: 1329-1333
NAID
Related Report
Peer Reviewed
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[Journal Article] Involvement of common intermediate 3-hydroxy-L-kynurenine in chromophore biosynthesis of quinomycin family antibiotics2011
Author(s)
Hirose, Y., Watanabe, K., Minami, A., Nakamura, T., Oguri, H., Oikawa,H.
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Journal Title
The Journal of Antibiotics
Volume: 64
Pages: 117-122
NAID
Related Report
Peer Reviewed
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