Synthesis of macrolactin A and itsderivatives using Z-selective intramolecular Horner-Wadsworth-Emmons reaction
| Project/Area Number |
22550095
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Synthetic chemistry
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| Research Institution | Gifu University |
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Principal Investigator |
ANDO Kaori 岐阜大学, 工学部, 教授 (70211018)
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| Co-Investigator(Renkei-kenkyūsha) |
OKA Natsuhisa 岐阜大学, 工学部, 准教授 (50401229)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | マクロラクチンA / 分子内HWE反応 / Z-選択的 / 誘導体合成 / 分子内ＨＷＥ反応 / Ｚ選択性 / マクロラクチンＡ / 合成化学 / Macrolactin A / Z選択的 / ホスホネート試薬 / 大環状ラクトン / Macrolactin A誘導体 |
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| Research Abstract |
Intramolecular Horner-Wadsworth-Emmons reaction of the substrates (ArO)2P(O)CH2CO2…CHO gave the 12- to 18-membered-ring Z-lactones highly selectively. While, the substrates (RO)2P(O)CH2CO2…CHO gave the E-lactones highly selectively. The synthesis of a macrolactin A derivative was performed by this method.
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Report
(4 results)
Research Products
(67 results)
