| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
Chiral phosphoric acid catalyzed enantioselective reduction of iminocyclobutenones prepared from alkynyl imines was carried out to give the chiral aminocyclobutenones with high enantioselectivities. Thermal rearrangement of chiral aminocyclobutenones in the presence of appropriate amines proceeded to afford the chiral cis- ortrans-β-lactams with high diastereo- and enantioselectivities, respectively. Moreover, thermal rearrangement of iminocyclobutenones gave the 4-quinolones in high yields.
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