Synthetic Study of Nitrogen Containing Compounds Based on New Reaction Mechanisms Using Alkynyl Imines as Starting Material
| Project/Area Number |
22550096
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Synthetic chemistry
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| Research Institution | Mie University |
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Principal Investigator |
HACHIYA Iwao 三重大学, 大学院・工学研究科, 准教授 (50312038)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | β-ラクタム / 含窒素化合物 / シクロブテノン / 不斉還元 / イミン / ケチミン / キラルリン酸 / 共役付加反応 / リン酸ジエステル触 / リン酸ジエステル触媒 |
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| Research Abstract |
Chiral phosphoric acid catalyzed enantioselective reduction of iminocyclobutenones prepared from alkynyl imines was carried out to give the chiral aminocyclobutenones with high enantioselectivities. Thermal rearrangement of chiral aminocyclobutenones in the presence of appropriate amines proceeded to afford the chiral cis- ortrans-β-lactams with high diastereo- and enantioselectivities, respectively. Moreover, thermal rearrangement of iminocyclobutenones gave the 4-quinolones in high yields.
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Report
(4 results)
Research Products
(70 results)
