• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Development of Novel Catalysts Utilizing Monoclonal Antibodies Specific for Optically Active Compounds with Thermoresponsive Particles

Research Project

Project/Area Number 22550112
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Polymer chemistry
Research InstitutionOsaka University

Principal Investigator

YAMAGUCHI Hiroyasu  大阪大学, 大学院・理学研究科, 教授 (00314352)

Co-Investigator(Kenkyū-buntansha) HARADA Akira  大阪大学, 大学院・理学研究科, 教授 (80127282)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsモノクローナル抗体 / 立体特異性 / キラル / 分子認識 / 熱応答性 / ビナフチル誘導体 / ヒドロゲル / 立体異性体 / 光学分離 / 抗原-抗体反応 / 特異性
Research Abstract

Monoclonal antibodies are considered to be one of the suitable proteins which can be used as a tailor-made chiral recognition reagent. In this study, a chiral binaphthyl derivative waschosen as a target molecule (hapten) which is a precursor for 2,2'-bis(diphenylphosphino)-1,1'-binaphthyl (BINAP), a widely used ligand in asymmetric metal-catalyzed reactions. Wedemonstrated that one of the monoclonal antibodies elicited against the binaphthyl derivative coulddifferentiate one of the enantiomers. We could clearly visualize chiral recognition events of the antibody by using poly-N-isopropylacrylamide (pNIPAM) bearing the chiral binaphthyl derivative.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (54 results)

All 2013 2012 2011 2010 Other

All Journal Article (8 results) (of which Peer Reviewed: 5 results) Presentation (37 results) (of which Invited: 3 results) Book (6 results) Remarks (1 results) Patent(Industrial Property Rights) (2 results) (of which Overseas: 2 results)

  • [Journal Article] Development and Characterization of a Monoclonal Antibody against Triacetone Triperoxide2013

    • Author(s)
      Matsumoto, T.; Yamaguchi, H.; Kamijo, K.; Akiyoshi, M.; Matsunaga, T.; Harada, A
    • Journal Title

      Bull. Chem. Soc. Jpn

      Volume: 86 Issue: 2 Pages: 198-202

    • DOI

      10.1246/bcsj.20120253

    • NAID

      10031155740

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Reversible Self-Assembly of Gels through Metal-Ligand Interactions2013

    • Author(s)
      Kobayashi, Y.
    • Journal Title

      Scientific Reports

      Volume: 3 Issue: 1 Pages: 2343-2343

    • DOI

      10.1038/srep01243

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 自己組織化超分子ポリマーの機能化-分子認識に基づく特異的なゲル集積-2012

    • Author(s)
      山口浩靖, 橋爪章仁, 高島義徳, 原田明
    • Journal Title

      化学工業

      Volume: 63 Pages: 96-104

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Journal Article] 分子認識を"この目で"見る-巨視的世界で実現した超分子のホスト-ゲスト相互作用-2012

    • Author(s)
      原田明, 山口浩靖, 高島義徳, 橋爪章仁
    • Journal Title

      月刊化学

      Volume: 67 Pages: 26-30

    • NAID

      40019329246

    • URL

      http://www.kagakudojin.co.jp/book/b101568.html

    • Related Report
      2012 Final Research Report
  • [Journal Article] 分子認識を“この目で”見る─巨視的世界で実現した超分子のホスト-ゲスト相互作用─2012

    • Author(s)
      原田明
    • Journal Title

      月刊化学

      Volume: 67 (6) Pages: 26-30

    • NAID

      40019329246

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Specific Biosensing with Supramolecular Complexes of Antibodies2011

    • Author(s)
      Yamaguchi, H.; Harada, A
    • Journal Title

      Chemical Sensors

      Volume: 27 Pages: 8-14

    • NAID

      40018912095

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Self-Assembly of Gels through Molecular Recognition of Cyclodextrins: Shape Selectivity for Linear and Cyclic Guest Molecules2011

    • Author(s)
      Yamaguchi, H.; Kobayashi, R.; Takashima, Y.; Hashidzume, A.; Harada, A
    • Journal Title

      Macromolecules

      Volume: 44 Issue: 8 Pages: 2395-2399

    • DOI

      10.1021/ma200398y

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Specific Biosensing with Supramolecular Complexes of Antibodies2011

    • Author(s)
      Yamaguchi, H. ; Harada, A.
    • Journal Title

      Chemical Sensors

      Volume: 27(印刷中)

    • NAID

      40018912095

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation]2012

    • Author(s)
      Yamaguchi, H.; Hashidzume, A.; Takashima, Y.; Harada, A
    • Organizer
      The 9th SPSJ International Polymer Conference
    • Place of Presentation
      神戸国際会議場 (神戸市).
    • Year and Date
      2012-12-13
    • Related Report
      2012 Final Research Report
  • [Presentation] Functionalized Catalytic and Energy Conversion Systems with Monoclonal Antibodies2012

    • Author(s)
      Yamaguchi, H.
    • Organizer
      Osaka University Macromolecular Symposium
    • Place of Presentation
      大阪大学 (豊中市)
    • Year and Date
      2012-11-10
    • Related Report
      2012 Final Research Report
  • [Presentation] 抗体修飾ゲルを用いた新規キラル識別・自己組織化システム2012

    • Author(s)
      永田健人, 山口浩靖, 原田明
    • Organizer
      第61回高分子討論会
    • Place of Presentation
      名古屋工業大学 (名古屋市)
    • Year and Date
      2012-09-20
    • Related Report
      2012 Final Research Report
  • [Presentation] Visualization of Specific Molecular Recognition Events by Monoclonal Antibodies or Cyclodextrins with Synthetic Polymers2012

    • Author(s)
      Yamaguchi, H.; Harada, A
    • Organizer
      International Symposium on Polymer Chemistry (PC2012)
    • Place of Presentation
      Changchun Institute of Applied Chemistry, Changchun (China).
    • Year and Date
      2012-06-05
    • Related Report
      2012 Final Research Report
  • [Presentation] 分子認識に基づくアガロースゲルとアクリルアミドゲルの特異的集積2012

    • Author(s)
      山口浩靖・劉俊彦・高島義徳・原田明
    • Organizer
      日本化学会第92春季年会
    • Place of Presentation
      慶応大学(神奈川県)
    • Year and Date
      2012-03-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] Visualization of Specific Molecular Recognition Events by Monoclonal Antibodies or Cyclodextrins with Synthetic Polymers2012

    • Author(s)
      Yamaguchi, H.
    • Organizer
      International Symposium on Polymer Chemistry (PC2012)
    • Place of Presentation
      Changchun Institute of Applied Chemistry, Changchun, China
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 抗体修飾ゲルを用いた新規キラル識別・自己組織化システム2012

    • Author(s)
      永田健人
    • Organizer
      第61回高分子討論会
    • Place of Presentation
      名古屋工業大学, 愛知県名古屋市
    • Related Report
      2012 Annual Research Report
  • [Presentation] 金属-リガンド相互作用によるゲルの自己集積2012

    • Author(s)
      小林裕一郎
    • Organizer
      第61回高分子討論会
    • Place of Presentation
      名古屋工業大学, 愛知県名古屋市
    • Related Report
      2012 Annual Research Report
  • [Presentation] Functionalized Catalytic and Energy Conversion Systems with Monoclonal Antibodies2012

    • Author(s)
      Yamaguchi, H.
    • Organizer
      Osaka University Macromolecular Symposium '12
    • Place of Presentation
      大阪大学, 大阪府豊中市
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Photoswitchable Gel Assembly through Molecular Recognition2012

    • Author(s)
      Yamaguchi, H.
    • Organizer
      The 9th SPSJ International Polymer Conference (IPC2012)
    • Place of Presentation
      神戸国際会議場, 兵庫県神戸市
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] モノクローナル抗体によるビナフチル誘導体のキラル認識と特異的検出システム2011

    • Author(s)
      山口浩靖, 尾高友紀, 原田明
    • Organizer
      第60回高分子討論会
    • Place of Presentation
      岡山大学 (岡山市)
    • Year and Date
      2011-09-30
    • Related Report
      2012 Final Research Report
  • [Presentation] モノクローナル抗体によるビナフチル誘導体のキラル認識と特異的検出システム2011

    • Author(s)
      山口浩靖・尾高友紀・原田明
    • Organizer
      第60回高分子討論会
    • Place of Presentation
      岡山大学(岡山県)
    • Year and Date
      2011-09-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] モノクローナル抗体を用いたキラル分別と特異的キラル可視化システム2011

    • Author(s)
      山口浩靖, 尾高友紀, 原田明
    • Organizer
      第5回バイオ関連化学シンポジウム
    • Place of Presentation
      つくば国際会議場 (つくば市)
    • Year and Date
      2011-09-14
    • Related Report
      2012 Final Research Report
  • [Presentation] モノクローナル抗体を用いたキラル分別と特異的キラル可視化システム2011

    • Author(s)
      山口浩靖・尾高友紀・原田明
    • Organizer
      第5回バイオ関連化学シンポジウム
    • Place of Presentation
      つくば国際会議場(茨城県)
    • Year and Date
      2011-09-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] Selective Assembly of Gels through Molecular Recognition of Cyclodextrins for Linear and Cyclic Guest Molecules2011

    • Author(s)
      Yamaguchi, H.; Kobayashi, R.; Takashima,Y; Hashidzume, A.; Harada, A.
    • Organizer
      ACC2011 6th Asian Cyclodextrin Conference
    • Place of Presentation
      The Australian National University (Australia)
    • Year and Date
      2011-08-31
    • Related Report
      2011 Annual Research Report
  • [Presentation] アビジンとビオチンとの特異的結合によるマクロスケールでの自己集積体の形成2011

    • Author(s)
      今井隆裕・高島義徳・山口浩靖・原田明
    • Organizer
      第57回高分子研究発表会(神戸)
    • Place of Presentation
      兵庫県民会館 (兵庫県)
    • Year and Date
      2011-07-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] Functionalized Catalytic and Energy Conversion Systems with Monoclonal Antibodies2011

    • Author(s)
      Yamaguchi, H.; Harada, A
    • Organizer
      Bio-inspired Materials and Functionalities
    • Place of Presentation
      Hampshire Hotel Plaza, Groningen(The Netherlands)
    • Year and Date
      2011-06-21
    • Related Report
      2012 Final Research Report
  • [Presentation] Functionalized Catalytic and Energy Conversion Systems with Monoclonal Antibodies2011

    • Author(s)
      Yamaguchi, H.; Harada, A.
    • Organizer
      Bio-inspired Materials and Functionalities
    • Place of Presentation
      Hampshire Hotel Plaza (The Netherlands)
    • Year and Date
      2011-06-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] モノクローナル抗体を用いたビナフチル誘導体の光学分割とエナンチオ選択的検出2011

    • Author(s)
      尾高友紀, 山口浩靖, 原田明
    • Organizer
      第60回高分子学会年次大会
    • Place of Presentation
      大阪国際会議場 (大阪市)
    • Year and Date
      2011-05-28
    • Related Report
      2012 Final Research Report
  • [Presentation] モノクローナル抗体を用いたビナフチル誘導体の光学分割とエナンチオ選択的検出2011

    • Author(s)
      尾高友紀・山口浩靖・原田明
    • Organizer
      第60回高分子学会年次大会
    • Place of Presentation
      大阪国際会議場 (大阪府)
    • Year and Date
      2011-05-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] 抗体を用いたピレンの分子間会合制御2011

    • Author(s)
      夛田まや子・山口浩靖・高島義徳・原田明
    • Organizer
      第60回高分子学会年次大会
    • Place of Presentation
      大阪国際会議場 (大阪府)
    • Year and Date
      2011-05-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] モノクローナル抗体を用いたビナフチル誘導体の簡便な光学分割とエナンチオ選択的検出法の構築2011

    • Author(s)
      尾高友紀, 山口浩靖, 原田明
    • Organizer
      日本化学会第91春季年会
    • Place of Presentation
      神奈川大学 (横浜市)
    • Year and Date
      2011-03-27
    • Related Report
      2012 Final Research Report
  • [Presentation] モノクローナル抗体を用いたビナフチル誘導体の簡便な光学分割とエナンチオ選択的検出法の構築2011

    • Author(s)
      尾高友紀・山口浩靖・原田明
    • Organizer
      日本化学会第91春季年会
    • Place of Presentation
      神奈川大学(横浜市)
    • Year and Date
      2011-03-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] ピレンダイマーに対するモノクロナール抗体を用いたピレンの光物性制御2011

    • Author(s)
      夛田まや子・山口浩靖・原田明
    • Organizer
      日本化学会第91春季年会
    • Place of Presentation
      神奈川大学(横浜市)
    • Year and Date
      2011-03-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] Functionalized Catalytic and Energy Conversion Systems with Monoclonal Antibodies2010

    • Author(s)
      Yamaguchi, H.; Harada, A
    • Organizer
      Pacifichem
    • Place of Presentation
      Honolulu, Hawaii (USA)
    • Year and Date
      2010-12-15
    • Related Report
      2012 Final Research Report
  • [Presentation] Functionalized catalytic and energy conversion systems with monoclonal antibodies2010

    • Author(s)
      Yamaguchi, H. ; Harada, A.
    • Organizer
      Pacifichem 2010
    • Place of Presentation
      Honolulu, Hawaii(USA)
    • Year and Date
      2010-12-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] 抗体結合によるピレンの光物性変化2010

    • Author(s)
      夛田まや子・山口浩靖・原田明
    • Organizer
      第4回バイオ関連化学シンポジウム
    • Place of Presentation
      大阪大学(豊中市)(招待講演)
    • Year and Date
      2010-09-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] モノクローナル抗体を用いた機能性超分子錯体の合成2010

    • Author(s)
      山口浩靖, 原田明
    • Organizer
      第4回バイオ関連化学シンポジウム
    • Place of Presentation
      大阪大学 (豊中市)
    • Year and Date
      2010-09-24
    • Related Report
      2012 Final Research Report
  • [Presentation] モノクローナル抗体を用いた機能性超分子錯体の合成2010

    • Author(s)
      山口浩靖・原田明
    • Organizer
      第4回バイオ関連化学シンポジウム
    • Place of Presentation
      大阪大学(豊中市)
    • Year and Date
      2010-09-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] 光学活性ビナフチル基に対するモノクローナル抗体の作製とその応用2010

    • Author(s)
      尾高友紀, 山口浩靖, 原田明
    • Organizer
      第59回高分子討論会
    • Place of Presentation
      北海道大学(札幌市)
    • Year and Date
      2010-09-16
    • Related Report
      2012 Final Research Report 2010 Annual Research Report
  • [Presentation] ピレンダイマーに対する抗体を用いたピレンの光物性制御2010

    • Author(s)
      夛田まや子・山口浩靖・原田明
    • Organizer
      第59回高分子討論会
    • Place of Presentation
      北海道大学(札幌市)
    • Year and Date
      2010-09-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] モノクローナル抗体を用いた機能性触媒・エネルギー変換システム2010

    • Author(s)
      山口浩靖, 原田明
    • Organizer
      第59回高分子討論会
    • Place of Presentation
      北海道大学(札幌市)
    • Year and Date
      2010-09-15
    • Related Report
      2012 Final Research Report 2010 Annual Research Report
  • [Presentation] 抗体と人工金属錯体との複合体を用いたエネルギー変換・触媒システ2010

    • Author(s)
      山口浩靖, 原田明
    • Organizer
      バイオインダストリー協会e バイオ(Electron-oriented Biotechnology)の展開」
    • Place of Presentation
      (財)バイオインダストリー協会 (東京都中央区)
    • Year and Date
      2010-08-24
    • Related Report
      2012 Final Research Report
  • [Presentation] 抗体と人工金属錯体との複合体を用いたエネルギー変換・触媒システム2010

    • Author(s)
      山口浩靖・原田明
    • Organizer
      バイオインダストリー協会e-バイオ(Electron-oriented Biotechnology)の展開
    • Place of Presentation
      (財)バイオインダストリー協会(東京・中央区)(招待講演)
    • Year and Date
      2010-08-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] ポルフィリン-抗体錯体を光増感剤とする光誘起水素発生システム2010

    • Author(s)
      山口浩靖・原田明
    • Organizer
      有機太陽電池シンポジウム
    • Place of Presentation
      京都大学(宇治市)(招待講演)
    • Year and Date
      2010-07-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] 光学活性ビナフチル基に対するモノクローナル抗体の作製とそれを用いた光学分割2010

    • Author(s)
      尾高友紀, 山口浩靖, 原田明
    • Organizer
      第59回高分子学会年次大会
    • Place of Presentation
      パシフィコ横浜 (横浜市)
    • Year and Date
      2010-05-28
    • Related Report
      2012 Final Research Report
  • [Presentation] 光学活性ビナフチル基に対するモノクローナル抗体の作製とそれを用いた光学分割2010

    • Author(s)
      尾高友紀・山口浩靖・原田明
    • Organizer
      第59回高分子学会年次大会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2010-05-28
    • Related Report
      2010 Annual Research Report
  • [Book] Supramolecular Polymer Chemistry (ISBN: 978-3-527-32321-0)2011

    • Author(s)
      Yamaguchi, H.; Harada, A
    • Publisher
      Wiley-VCH
    • Related Report
      2012 Final Research Report
  • [Book] Chemosensors: Principles, Strategies, and Applications (ISBN: 978-0-470-59206-9)2011

    • Author(s)
      Yamaguchi, H.; Harada, A
    • Publisher
      John Wiley & Sons, Inc.
    • Related Report
      2012 Final Research Report
  • [Book] Supramolecular Polymer Chemistry (ISBN : 978-3-527-32321-0)2011

    • Author(s)
      Yamaguchi, H.; Harada, A.(共著)
    • Publisher
      Wiley-VCH
    • Related Report
      2011 Annual Research Report
  • [Book] Chemosensors : Principles, Strategies, and Applications (ISBN : 978-0-470-59206-9)2011

    • Author(s)
      Yamaguchi, H.; Harada, A.(共著)
    • Publisher
      John Wiley & Sons, Inc.
    • Related Report
      2011 Annual Research Report
  • [Book] Supramolecular Polymer Chemistry2011

    • Author(s)
      Yamaguchi, H. ; Harada, A.(共著)
    • Publisher
      Wiley-VCH(印刷中)
    • Related Report
      2010 Annual Research Report
  • [Book] Chemosensors : Principles, Strategies, and Applications2011

    • Author(s)
      Yamaguchi, H. ; Harada, A.(共著)
    • Publisher
      Wiley(印刷中)
    • Related Report
      2010 Annual Research Report
  • [Remarks] ホームページ情報

    • URL

      http://www.chem.sci.osaka-u.ac.jp/lab/yamaguchi/index.html

    • Related Report
      2012 Final Research Report
  • [Patent(Industrial Property Rights)] Antibody against Explosive Material and Method for Constructing Same2010

    • Inventor(s)
      原田明・山口浩靖・松本達・上條憲一
    • Industrial Property Rights Holder
      国立大学法人大阪大学・日本電気株式会社
    • Filing Date
      2010-05-18
    • Related Report
      2010 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] Antibody against Anti-Malarial Drug and Monoclonal Antibody, and Method for Constructing Same2010

    • Inventor(s)
      原田明・山口浩靖・松本達・上條憲一
    • Industrial Property Rights Holder
      国立大学法人大阪大学・日本電気株式会社
    • Filing Date
      2010-05-18
    • Related Report
      2010 Annual Research Report
    • Overseas

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi