Detoxication of fluorine-bearing pharmaceutical drugs by advanced oxidation processes
| Project/Area Number |
22550141
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Environmental chemistry
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| Research Institution | Meisei University |
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Principal Investigator |
HIDAKA Hisao 明星大学, 連携研究センター, 主幹研究員 (70062312)
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| Co-Investigator(Renkei-kenkyūsha) |
TAKAMURA Takeji 神奈川工科大学, 大学院・応用化バイオ サイエンス専攻, 教授 (50342910)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | オゾン酸化 / 高度酸化技術 / 光還元触媒 / 医薬品汚染 / 水質浄化 / 含フッ素医薬品 / 変異原性 / 酸化ガリウム / 脱フッ素反応 / 半導体光触媒 / 医薬品分解 / 水質汚染防止 / 変異原性試験 / 光触媒酸化 / 向精神薬 |
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| Research Abstract |
Fluorine-bearing pharmaceuticals are acted as an endocrine disruptor to cause serious contamination in ecological aquatic environment. The advanced oxidation processes in the addition of ozone and/or hydrogen peroxide led the detoxication for recalcitrant chemicals. In order to sever the strong C-F bond, the photoassisted defluorination by gallium oxide catalysis was carried out to generate fluorine ions. The Pt-loading Ga2O3 catalyst enhanced the defluorination yield. The opimal conditions of defluorination were investigated. Therefore, non-degradable substances were easily mineralized and their degraded intermediates had no mutagenicity by the Ames test.
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Report
(5 results)
Research Products
(30 results)
