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Sub-wavelength 3-dimentional imaging of biological tissue

Research Project

Project/Area Number 22560032
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied optics/Quantum optical engineering
Research InstitutionUniversity of Tsukuba

Principal Investigator

ITOH Masahide  筑波大学, 数理物質系, 教授 (30150874)

Co-Investigator(Renkei-kenkyūsha) YATAGAI Toyohiko  宇都宮大学, オプティックス教育研究センター, 教授 (90087445)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords3次元計測 / 画像処理 / 生体計測 / 3次元計測 / 光学顕微鏡 / MTF / コヒーレンス / 微分干渉 / 光学的伝達関数 / デフォーカス / セクショニング / デフォーカス特性 / 訣像光学系
Research Abstract

We established the quantitative technique to visualize the shape and structure of biological tissue which has a small difference of a refractive index. We were able to get the sub-wavelength phase distribution as depth by using the phase modulation differential interference microscope which we developed. Moreover, when we observe three-dimensional object there was a problem which disturbs reconstruction with blurred image before and behind an exact image plane. Consequently, we combined the Nearest Neighbor Deblurring method with the phase reconstruction technique of a phase modulation differential interference microscope, and confirmed its availability.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (30 results)

All 2013 2012 2011 2010 Other

All Journal Article (11 results) (of which Peer Reviewed: 11 results) Presentation (17 results) Remarks (2 results)

  • [Journal Article] Unique ZnS-SiO_2 Morphologies Reflecting a Laser-Induced Heat Distribution2013

    • Author(s)
      Tetsuji Mori and Masahide Itoh
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: Vol.52 Issue: 4R Pages: 48004-48004

    • DOI

      10.7567/jjap.52.048004

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Precise and rapid distance measurements by scatterometry2012

    • Author(s)
      Tesuya Hoshino, Toyohiko Yatagai, and Masahide Itoh
    • Journal Title

      Optics Express

      Volume: Vol. 20, Issue 4 Issue: 4 Pages: 3954-3966

    • DOI

      10.1364/oe.20.003954

    • NAID

      120007130661

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of vertical coupling between a 2D photonic crystal cavity and a hydrogenated-amorphous-silicon-wire waveguide2012

    • Author(s)
      Makoto Okanoa, Tomoya Yamadab, Youichi Sakakibaraa, Toshihiro Kameia, Jun-ichiro Sugisakab, Noritsugu Yamamotoa, Masahide Itoh, Takeyoshi Sugayab, Kazuhiro Komori, Masahiko Mori
    • Journal Title

      Photonics and Nanostructures - Fundamentals and Applications

      Volume: 10 Issue: 3 Pages: 287-295

    • DOI

      10.1016/j.photonics.2011.06.006

    • NAID

      120007137257

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Demonstration of the wide control range Q factor of ring cavity with ultrashort directional coupler and curved photonic-crystal ring waveguide2012

    • Author(s)
      Jun-ichiro Sugisaka, Noritsugu Yamamoto, Makoto Okano, Kazuhiro Komori and Masahide Itoh
    • Journal Title

      JOSA B

      Volume: 29 Issue: 6 Pages: 1521-1527

    • DOI

      10.1364/josab.29.001521

    • NAID

      120007137270

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhancement of the Q value of a microring resonator by introducing curved photonic crystal waveguides2012

    • Author(s)
      Jun-ichiro Sugisaka, Noritsugu Yamamoto, Makoto Okano, Kazuhiro Komori and Masahide Itoh
    • Journal Title

      JOSA B

      Volume: 29 Issue: 7 Pages: 1599-1605

    • DOI

      10.1364/josab.29.001599

    • NAID

      120007137256

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A columnar model explaining long-term memory2012

    • Author(s)
      Tetsuya Hoshino, Toyohiko Yatagai and Masahide Itoh
    • Journal Title

      Optical Memory and Neural Networks

      Volume: 21 Issue: 4 Pages: 209-218

    • DOI

      10.3103/s1060992x12040042

    • NAID

      120007128784

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High-penetration swept source Doppler optical coherence angiography by fully numerical phase stabilization2012

    • Author(s)
      Young-Joo Hong, Shuichi Makita, Franck Jaillon, Myeong Jin Ju, Eun Jung Min, Byoeng Ha Lee, Masahide Itoh, Masahiro Miura, Yoshiaki Yasuno
    • Journal Title

      Optics Express

      Volume: 20 Issue: 3 Pages: 2740-2760

    • DOI

      10.1364/oe.20.002740

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Short Photonic-Crystal Directional Coupling Optical Switch of Extended Optical Bandwidth Using Flat Dispersion2011

    • Author(s)
      Sugisaka, Jun-ichiro; Yamamoto, Noritsugu; Okano, Makoto; Komori, Kazuhiro; Itoh, Masahide
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: Volume 50, Issue 3 Issue: 3R Pages: 032201-032201

    • DOI

      10.1143/jjap.50.032201

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Shape analysis of wavelength-insensitive grating in the resonance domain2011

    • Author(s)
      Tetsuya Hoshino, Saswatee Banerjee, James B. Cole, Masahide Itoh and Toyohiko Yatagai
    • Journal Title

      Optics Communications

      Volume: 284 Issue: 10-11 Pages: 2466-2472

    • DOI

      10.1016/j.optcom.2011.01.056

    • NAID

      120007130914

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Detection of falsification of security documents using white light interferometer2010

    • Author(s)
      Shigeru Sugawara, Shoichi Nakanishi, Masahide Itoh, and Toyohiko Yatagai
    • Journal Title

      Optics and Lasers in Engineering

      Volume: 48 Pages: 448-452

    • NAID

      120007138197

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Widening the range of high-precision quantitative measurement in retardation- modulated differential interference microscope2010

    • Author(s)
      Hiroshi Ishiwata, Hiroki Nagai, Toshihisa Naka and Masahide Itoh
    • Journal Title

      Optical Review

      Volume: 17 Pages: 214-217

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Presentation] 位相変調型微分干渉顕微鏡を用いた位相再生手法へのNearest Neighbor Deblurring の応用提案2013

    • Author(s)
      笠木隆裕,石渡裕,伊藤雅英
    • Organizer
      第60回応用物理学関係連合講演会
    • Place of Presentation
      神奈川工科大学
    • Year and Date
      2013-03-27
    • Related Report
      2012 Final Research Report
  • [Presentation] 位相変調型微分干渉顕微鏡を用いた位相再生手法へのNearest Neighbor Deblurring の応用提案2013

    • Author(s)
      笠木隆裕,石渡裕,伊藤雅英
    • Organizer
      第60回応用物理学会学術講演会
    • Place of Presentation
      神奈川工科大学
    • Year and Date
      2013-03-27
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] フーリエ変換による位相アンラッピングの重みづけ法2012

    • Author(s)
      風間至弘,伊藤雅英
    • Organizer
      第59回応用物理学関係連合講演会
    • Place of Presentation
      早稲田大学
    • Year and Date
      2012-03-18
    • Related Report
      2012 Final Research Report
  • [Presentation] 透過型位相変調型微分干渉顕微鏡におけるセクショニングマスク法の計測範囲の検討2012

    • Author(s)
      笠木隆裕,石渡裕,伊藤雅英
    • Organizer
      第59回応用物理学関係連合講演会
    • Place of Presentation
      早稲田大学
    • Year and Date
      2012-03-17
    • Related Report
      2012 Final Research Report
  • [Presentation] 透過型位相変調型微分干渉顕微鏡におけるセクショニングマスク法の計測範囲の検討2012

    • Author(s)
      笠木隆裕, 石渡裕, 伊藤雅英
    • Organizer
      第59回応用物理学関係連合講演会
    • Place of Presentation
      早稲田大学(東京)
    • Year and Date
      2012-03-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] フーリエ変換による位相アンラッピングの重みづけ法2012

    • Author(s)
      風間至弘, 伊藤雅英
    • Organizer
      第59回応用物理学関係連合講演会
    • Place of Presentation
      早稲田大学(東京)
    • Year and Date
      2012-03-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] 柱状散乱体による脳の記憶の光学的モデル2012

    • Author(s)
      星野鉄哉,谷田貝豊彦,伊藤雅英
    • Organizer
      Optics & Photonics Japan 2012
    • Place of Presentation
      タワーホール船堀
    • Related Report
      2012 Annual Research Report
  • [Presentation] 生体計測における位相変調型微分干渉顕微鏡の高精度セクショニング化の提案2011

    • Author(s)
      笠木隆裕, 中俊久, 石渡裕, 伊藤雅英
    • Organizer
      Optics & Photonics Japan
    • Place of Presentation
      大阪大学
    • Year and Date
      2011-11-29
    • Related Report
      2012 Final Research Report
  • [Presentation] 位相変調型微分干渉顕微鏡を用いた球形状試料の高精度位相再生手法2011

    • Author(s)
      中俊久, 笠木隆裕, 石渡裕, 伊藤雅英
    • Organizer
      Optics & Photonics Japan
    • Place of Presentation
      大阪大学
    • Year and Date
      2011-11-29
    • Related Report
      2012 Final Research Report
  • [Presentation] 生体計測における位相変調型微分干渉顕微鏡の高精度セクショニング化の提案2011

    • Author(s)
      笠木隆裕, 中俊久, 石渡裕, 伊藤雅英
    • Organizer
      日本光学会年次学術講演会Optics & Photonics Japan 2011
    • Place of Presentation
      大阪大学(大阪)
    • Year and Date
      2011-11-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] 位相変調型微分干渉顕微鏡を用いた球形状試料の高精度位相再生手法2011

    • Author(s)
      中俊久, 笠木隆裕, 石渡裕, 伊藤雅英
    • Organizer
      日本光学会年次学術講演会Optics & Photonics Japan 2011
    • Place of Presentation
      大阪大学(大阪)
    • Year and Date
      2011-11-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] A new three-dimensional measurement method for retardation-modulated differential interference contrast microscope2011

    • Author(s)
      M.Itoh, H.Nagai, H.Ishiwata
    • Organizer
      Optics in Engineering 2011
    • Place of Presentation
      Turku/Abo, Finland
    • Year and Date
      2011-09-09
    • Related Report
      2011 Annual Research Report
  • [Presentation] Analyzing defocus characteristics in phase contrast microscopy and in differential interference contrast microscopy2011

    • Author(s)
      H.Ishiwata, T.Kasaki, M.Itoh
    • Organizer
      Optics in Engineering 2011
    • Place of Presentation
      Turku/Abo, Finland
    • Year and Date
      2011-09-09
    • Related Report
      2011 Annual Research Report
  • [Presentation] 位相物体のデフォーカス特性の種観察法よる比較2011

    • Author(s)
      笠木隆裕, 中俊久, 石渡裕, 伊藤雅英
    • Organizer
      第58回応用物理学関係連合講演会
    • Place of Presentation
      神奈川工科大学
    • Year and Date
      2011-03-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] シアー方向の異なる2枚のRM-DIC像を用いた位相再生手法の検討2011

    • Author(s)
      中俊久, 永井宏樹, 石渡裕, 伊藤雅英
    • Organizer
      第58回応用物理学関係連合講演会
    • Place of Presentation
      神奈川工科大学
    • Year and Date
      2011-03-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] 位相変調型微分干渉顕微鏡の計測範囲の3次元拡張2010

    • Author(s)
      永井 宏樹,俊久, 笠木隆裕, 石渡裕, 伊藤雅英
    • Organizer
      Optics & Photonics Japan
    • Place of Presentation
      中央大学 駿河台記念館
    • Year and Date
      2010-11-08
    • Related Report
      2012 Final Research Report
  • [Presentation] シアー方向の異なる2枚のRM-DIC像を用いた位相再生手法の検討2010

    • Author(s)
      中俊久, 永井 宏樹, 石渡裕, 伊藤雅英
    • Organizer
      Optics & Photonics Japan
    • Place of Presentation
      中央大学 駿河台記念館
    • Year and Date
      2010-11-08
    • Related Report
      2012 Final Research Report
  • [Remarks]

    • URL

      http://gabor.bk.tsukuba.ac.jp/

    • Related Report
      2012 Final Research Report
  • [Remarks]

    • URL

      http://gabor.bk.tsukuba.ac.jp/

    • Related Report
      2011 Annual Research Report

URL: 

Published: 2010-11-30   Modified: 2019-07-29  

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