Development of nano/micro-scale heating method using magnetic particles

• Project/Area Number: 22560209
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Thermal engineering
• Research Institution: Toyo University
• Principal Investigator: MORIMOTO Hisao 東洋大学, 理工学部, 准教授 (00385957)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000); Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 熱工学 / マイクロ / ナノスケール伝熱 / マイクロ・ナノスケール伝熱

Research Abstract

A new nano/micro-scale heating method was developed combining the hysteresis loss heating of ferromagnetic particles under a high frequency alternating magnetic field and the method of manipulating magnetic particles using an external magnetic field. It was shown that the activation and manipulation of enzymes immobilized on ferromagnetic particles can be carried out utilizing the present method.

Research Products

• [Journal Article] Amyloid- binding aptam er conjugated curcumin- PLGA nanopa rticle for potential use in Alzheime r's disease (2012)
  • Author(s): A. Mathew, A. Aravind, D. Brahathees waran, T. Fukuda, Y. Nagaoka, T. Has umura, S. Iwai, H. Morimoto, Y. Yoshida, T. Maekawa, K. Venugopal and D. S. Kumar
  • Journal Title: BioNanoSci Volume: Vol.2 Issue: 2 Pages: 83-93
  • DOI: 10.1007/s12668-012-0040-y
  • Peer Reviewed
• [Journal Article] Curcumin loaded-PLGA nanopartic les conjugated with Tet-1 peptide fo r potential use in Alzheimer's disea se (2012)
  • Author(s): A. Mathew, T. Fukuda, Y. Nagaoka, T.Hasumura, H. Morimoto, Y. Yoshida, T. Maekawa, K. Venugopal, D. S. Kuma r
  • Journal Title: PLoS ONE Volume: Vol.7 Issue: 3 Pages: e32616-e32616
  • DOI: 10.1371/journal.pone.0032616
  • Peer Reviewed
• [Journal Article] Ordered complex structures for med by paramagnetic particles via se lf-assembly under an ac/dc combined magnetic field (2011)
  • Author(s): Y. Nagaoka, H. Morimoto and T. Maeka wa
  • Journal Title: Langmuir Volume: Vol.27 Issue: 15 Pages: 9160-9164
  • DOI: 10.1021/la201156q
  • Peer Reviewed
• [Journal Article] Cluster-cluster aggregations of s uperparamagnetic particles in a rota tional magnetic field (2011)
  • Author(s): T. Ukai, H. Morimoto and T. Maekawa
  • Journal Title: Phys. Rev. E Volume: Vol.83 Issue: 6 Pages: 61406-61406
  • DOI: 10.1103/physreve.83.061406
  • Peer Reviewed
• [Journal Article] Aptamer conjugated magnetic n anoparticles as nanosurgeons (2010)
  • Author(s): B. G. Nair, Y. Nagaoka, H. Morimoto, Y. Yoshida, T. Maekawa and D. S. Ku mar
  • Journal Title: Nano technology Volume: Vol.21 Issue: 45 Pages: 455102-455102
  • DOI: 10.1088/0957-4484/21/45/455102
  • Peer Reviewed
• [Journal Article] Aptamer conjugated magnetic nanoparticles as nanosurgeons (2010)
  • Author(s): B.G.Nair, Y.Nagaoka,, H.Morimoto, Y.Yoshida, T.Maekawa, D.S.Kumar
  • Journal Title: Nanotechnology Volume: 21
  • Peer Reviewed
• [Presentation] Cluster s tructures of ferromagnetic nanopart icles formed in a narrow gap (2012)
  • Author(s): T. Iida and H. Morimoto
  • Organizer: 7th International Conference on Surface s, Coatings and Nanostructured Mate rials (NANOSMAT 2012) (
  • Place of Presentation: Plague, Czech Republic
  • Year and Date: 2012-09-20
• [Presentation] A ctivity of an enzyme immobilized on ferromagnetic particles under an ac magnetic field (2012)
  • Author(s): M. Suzuki, A. Aki, T. Mizuki, R. Us ami, T. Maekawa and H. Morimoto
  • Organizer: 7th Internationa l Conference on Surfaces, Coatings and Nanostructured Materials (NANOS MAT 2012) (
  • Place of Presentation: Pla gue, Czech Republic
  • Year and Date: 2012-09-20
• [Presentation] Polymerase chain rea ction utilizing DNA polymerase/magnetic particle hybrid (2012)
  • Author(s): S. Suzuki, M. Suzuki, T. Mizuki and H. Morimoto
  • Organizer: 7th Internat ional Conference on Surfaces, Coati ngs and Nanostructured Materials (N ANOSMAT 2012) (
  • Place of Presentation: Plague, Czech Republic
  • Year and Date: 2012-09-20
• [Presentation] Dynamics of magneti cally controlled magnetic nano/micro objects on the surface of a subst rate (2012)
  • Author(s): Y. Nagaoka, T. Ukai, M. Suzuki, R.Hironaga, H. Morimoto, N. Grobert a nd T. Maekawa
  • Organizer: 7th International Conference on Surfaces, Coatings and Nanostru ctured Materials (NANOSMAT 2012)
  • Place of Presentation: Plague, Czech Republic
  • Year and Date: 2012-09-20
• [Presentation] 強磁性粒子のヒステリシス損熱を利用した酵素の活性化 (2012)
  • Author(s): 鈴木政史,安喜敦士,水木徹,宇佐美論,前川透,森本久雄
  • Organizer: 化学工学会第77年会
  • Place of Presentation: 東京・工学院大学
  • Year and Date: 2012-03-15
• [Presentation] 強磁性粒子のヒステリシス損熱を利用した酵素の活性化 (2012)
  • Author(s): 鈴木政史, 安喜敦士, 水木徹, 宇佐美論, 前川透, 森本久雄
  • Organizer: 化学工学会第77年会
  • Place of Presentation: 工学院大学新宿キャンパス
  • Year and Date: 2012-03-15
• [Presentation] Activity of an enzyme immobilized on ferromagnetic particles under an ac magnetic field (2012)
  • Author(s): M. Suzuki, A. Aki, T. Mizuki, R. Usami, T. Maekawa and H. Morimoto
  • Organizer: 7th International Conference on Surfaces, Coatings and Nanostructured Materials (NANOSMAT 2012)
  • Place of Presentation: Czech Republic
• [Presentation] Polymerase chain reaction utilizing DNA polymerase/magnetic particle hybrid (2012)
  • Author(s): S. Suzuki, M. Suzuki, T. Mizuki and H. Morimoto
  • Organizer: 7th International Conference on Surfaces, Coatings and Nanostructured Materials (NANOSMAT 2012)
  • Place of Presentation: Czech Republic
• [Presentation] Dynamics of magnetically controlled magnetic nano/micro objects on the surface of a substrate (2012)
  • Author(s): Y. Nagaoka, T. Ukai, M. Suzuki, R. Hironaga, H. Morimoto, N. Grobert and T. Maekawa
  • Organizer: 7th International Conference on Surfaces, Coatings and Nanostructured Materials (NANOSMAT 2012)
  • Place of Presentation: Czech Republic
• [Presentation] Cluster structures of ferromagnetic nanoparticles formed in a narrow gap (2012)
  • Author(s): T. Iida and H. Morimoto
  • Organizer: 7th International Conference on Surfaces, Coatings and Nanostructured Materials (NANOSMAT 2012)
  • Place of Presentation: Czech Republic
• [Presentation] Application of bi ofunctionalized magnetic nanopartic les for cell manipulation studies (2011)
  • Author(s): B. G. Nair, Y. Nagaoka, T. Fukuda, T. Mizuki, H. Morimoto, D. S. Kumar and T. Maekawa
  • Organizer: Nanocon2011
  • Place of Presentation: Brno, Czech Republic
  • Year and Date: 2011-09-22
• [Presentation] Application of biofunctionalized magnetic nanoparticles for cell manipulation studies (2011)
  • Author(s): B.G.Nair, Y.Nagaoka, T.Fukuda, T.Mizuki, H.Morimoto, D.S.Kumar, T.Maekawa
  • Organizer: Nanocon2011
  • Place of Presentation: Hotel Voronez I (Brno, Czech Republic)
  • Year and Date: 2011-09-22
• [Presentation] E ncouragement of enzyme reaction uti lizing hysteresis loss heating of f erromagnetic particles (2011)
  • Author(s): M. Suzuki, A. Aki, T. Mizuki, R. Usami, T. Maekawa and H. Morimoto
  • Organizer: 15th Inter national Symposium on Applied Elect romagnetics and Mechanics
  • Place of Presentation: Naples, Italy
  • Year and Date: 2011-09-09
• [Presentation] Encouragement of biochemical reactions b y rotating chain clusters in a rota tional magnetic field (2011)
  • Author(s): T. Hashimoto, Y. Nagaoka, T. Mizuki,H. Morimoto and T. Maekawa
  • Organizer: 15th Intern ational Symposium on Applied Electr omagnetics and Mechanics
  • Place of Presentation: Naples, Italy
  • Year and Date: 2011-09-09
• [Presentation] Encouragement of enzyme reaction utilizing hysteresis loss heating of ferromagnetic particles (2011)
  • Author(s): M.Suzuki, A.Aki, T.Mizuki, R.Usami, T.Maekawa, H.Morimoto
  • Organizer: 15th International Symposium on Applied Electromagnetics and Mechanics
  • Place of Presentation: Royal Continental Hotel (Naples, Italy)
  • Year and Date: 2011-09-09
• [Presentation] Cluster structures f ormed by paramagnetic particles sub jected to a dc magnetic field (2011)
  • Author(s): K. Hoshino, T. Ukai, T. Maekawa and H. Morimoto
  • Organizer: 15t h International Symposium on Applied Electromagnetics and Mechanics
  • Place of Presentation: Naples, Italy
  • Year and Date: 2011-09-08
• [Presentation] 強磁性粒子のヒステリシス損熱を利用した酵素反応促進法の開発 (2011)
  • Author(s): 鈴木政史,安喜敦士,水木徹,宇佐美論,前川透,森本久雄
  • Organizer: 化学工学会第76年会
  • Place of Presentation: 東京・東京農工大学
  • Year and Date: 2011-03-22
• [Presentation] 強磁性粒子のヒステリシス損熱を利用した酵素反応促進法の開発 (2011)
  • Author(s): 鈴木政史, 安喜敦士, 水木徹, 宇佐美論, 前川透, 森本久雄
  • Organizer: 化学工学会 第76年会
  • Place of Presentation: 東京農工大学 小金井キャンパス
  • Year and Date: 2011-03-22
• [Presentation] Activation of enzyme utilizing hysteresis loss heating of ferromagnetic particles (2010)
  • Author(s): M.Suzuki, A.Aki, T.Mizuki, R.Usami, T.Maekawa, H.Morimoto
  • Organizer: International Soft Matter Conference 2010
  • Place of Presentation: Granada exhibition and conference centre (Granada, Spain)
  • Year and Date: 2010-07-05
• [Presentation] Dynamics of magnetic colloidal particles on a nonmagnetic substrate under a rotational magnetic field (2010)
  • Author(s): R.Hironaga, Y.Nagaoka, T.Ukai, H.Morimoto, T.Maekawa
  • Organizer: International Soft Matter Conference 2010
  • Place of Presentation: Granada exhibition and conference centre (Granada, Spain)
  • Year and Date: 2010-07-05
• [Presentation] A ctivation of enzyme utilizing hysteresis loss heating of ferromagnetic particles (2010)
  • Author(s): M. Suzuki, A. Aki, T. Mizuki, R. Us ami, T. Maekawa and H. Morimoto
  • Organizer: International Soft Mat ter Conference 2010
  • Place of Presentation: Granada, Spain
• [Presentation] Dynamicsof magnetic colloidal particles on a nonmagnetic substrate under a ro tational magnetic field (2010)
  • Author(s): R. Hironaga, Y. Nagaoka, T. Ukai, H. Morimoto and T. Maekawa
  • Organizer: Internati onal Soft Matter Conference 2010
  • Place of Presentation: Granada,Spain
• [Presentation] Aggregation of superparamagnetic particles in a rotational magnetic field (2010)
  • Author(s): T. Ukai, H. Morimoto and T. Maekawa
  • Organizer: International Soft Matter Conference 2010
  • Place of Presentation: Granada,Spain
• [Presentation] Cluster structures formed by magnetic colloidal particles under fluctuating magnetic fields (2010)
  • Author(s): Y. Nagaoka, H. Morimoto and T. Maek awa
  • Organizer: Inter national Soft Matter Conference 2010
  • Place of Presentation: Granada,Spain