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Studies on biological control theory for analysis and synthesis of molecule attractors fluctuated by intrinsic noise

Research Project

Project/Area Number 22560454
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Control engineering
Research InstitutionWaseda University

Principal Investigator

UCHIDA Kenko  早稲田大学, 理工学術院, 教授 (80063808)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Keywords制御理論 / 生物制御 / アトラクター制御 / 制御工学
Research Abstract

By using mathematical models and investigating the control mechnism that generates biological rhythms against intrinsic noises, which is the objective of this study, we have the following results: (1) We proposed evaluation measures of amplitude and periodicity fluctuations of oscillatory attractors by intrinsic noise; we characterized (2) the parameter set and (3) the feedback structure that make the rhythm more robust against intrinsic noise ; (4) we built the mathematical model that presents simultaneously the temperature compensation and the temperature entrainment when intrinsic noise can be neglected.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (16 results)

All 2013 2012 2011 2010 Other

All Journal Article (12 results) (of which Peer Reviewed: 12 results) Presentation (4 results)

  • [Journal Article] A gain scheduling model of temperature compensation for circadian rhythm of Cyanobacteria2013

    • Author(s)
      M.Shimada, K.Uchida
    • Journal Title

      Proc. the 9th Asian Control Conference

      Volume: (Accepted)

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Discovery of a novel type of autophagy targeting RNA2013

    • Author(s)
      Y.Fujiwara, A.Furuta, H.Kikuchi, S.Aizawa, Y.Hatanaka, C.Konya, K.Uchida, A.Yoshimura, Y.Tamai, K.Wada, T.Kabuta
    • Journal Title

      Autophagy

      Volume: Vol.9:3 Pages: 403-409

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] A Gain Scheduling Model of Temperature Compensation for Circadian Rhythm of Cyanobacteria2013

    • Author(s)
      M. Shimada, K. Uchida
    • Journal Title

      Proc. of 9th Asian Control Conference 2013

      Volume: CD-ROM Pages: 1-6

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Parkinson's disease-associated mutations in α-synuclein and UCH-L1 inhibit the unconventional secretion of UCH-L12011

    • Author(s)
      C.Konya, Y.Hatanaka, Y.Fujiwara, K.Uchida, Y.Nagai, K.Wada
    • Journal Title

      Neurochemistry International

      Volume: Vol.59 Pages: 251-258

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Robustness analysis and optimization of circadian clocks fluctuated by intrinsic noise2011

    • Author(s)
      Y.Ito, S.Kawachi, K.Uchida
    • Journal Title

      Proc. of the 8th Asian Control Conference

      Pages: 506-511

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Robustness Analysis and Optimization of Circadian Clocks fluctuated by Intrinsic Noise2011

    • Author(s)
      Y.Ito, S.Kawachi, K.Uchida
    • Journal Title

      Proc.of 2011 8th Asian Control Conference

      Volume: (CD-ROM) Pages: 506-511

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Parkinson's disease-associated mutations in alpha-synuclein and UCH-L1 inhibit the unconventional secretion of UCH-L12011

    • Author(s)
      Konya, C.
    • Journal Title

      Neurochem Int

      Volume: 59 Issue: 2 Pages: 251-258

    • DOI

      10.1016/j.neuint.2011.05.012

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Formulas for intrinsic noise evaluation in oscillatory genetic networks2010

    • Author(s)
      Y.Ito, K.Uchida
    • Journal Title

      J. of Theoretical Biology

      Volume: Vol.267 Pages: 223-234

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Performance evaluation of circadian clocks by intrinsic noise2010

    • Author(s)
      Y.Ito, K.Uchida
    • Journal Title

      Proc. of 2010 IEEE Multi-conference on Systems and Control

      Pages: 506-511

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of a novel chemical potentiator and inhibitors of UCH-L1 by in silico drug screening2010

    • Author(s)
      T.Mitsui, K.Hirayama, S.Aoki, K.Nishikawa, K.Uchida, 他3名
    • Journal Title

      Neurochemistry International

      Volume: 56 Pages: 679-686

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Formulas for intrinsic noise evaluation in oscillatory genetic networks2010

    • Author(s)
      Y.Ito, K.Uchida
    • Journal Title

      Journal of Theoretical Biology

      Volume: 267 Pages: 223-234

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Performance Evaluation of Circadian Clocks Fluctuated by Intrinsic Noise2010

    • Author(s)
      Y.Ito, K.Uchida
    • Journal Title

      Proc.of 2010 IEEE International Conf.on Control Applications

      Volume: (CD-ROM) Pages: 506-511

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 異なる構造をもつ振動的遺伝子ネットワークに対する内因的ゆらぎの評価2012

    • Author(s)
      日出間 河内 内田
    • Organizer
      第55回自動制御連合講演会
    • Place of Presentation
      京都大学
    • Related Report
      2012 Annual Research Report
  • [Presentation] 内因的ノイズを考慮した概日リズムモデルの評価とロバスト性解析2010

    • Author(s)
      伊藤, 河内, 内田
    • Organizer
      第53回自動制御連合講演会
    • Place of Presentation
      高知城ホール
    • Year and Date
      2010-11-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] 異なる構造をもつ振動的遺伝子ネットワークに対する内因的ゆらぎの評価

    • Author(s)
      日出間俊、河内翔大、内田健康
    • Organizer
      第55回自動制御連合講演会
    • Related Report
      2012 Final Research Report
  • [Presentation] 内因的ノイズを考慮した概日リズムの評価とロバスト性解析

    • Author(s)
      伊藤洋平、河内翔大、内田健康
    • Organizer
      第53回自動制御連合講演会
    • Related Report
      2012 Final Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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