| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
Plant cells often increase their cellular DNA content (ploidy) during plant development, through the modified cell cycle where DNA replication occurs repeatedly without intervening cell division. Although it has been generally believed that increased cellular ploidy may be important for the control of cell size, metabolic activity, and cell differentiation, little is known about the regulatory mechanisms of this processes. In this study, we have focused on the two factors, GIG1 and SCL, that may have important roles in increasing cellular ploidy. We showed that GIG1 may negatively regulate ploidy increase by inhibiting a specific protein degradation system acing during G2 and mitosis. On the other hand, SCL may accelerate increasing ploidy by transcriptional repression of genes involved in DNA replication, possibly during M phase in the cell cycle.
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