Roles of autocrine signaling molecules in epithelial branching morphogenesis

• Project/Area Number: 22570059
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Morphology/Structure
• Research Institution: Chiba University
• Principal Investigator: NOGAWA Hiroyuki 千葉大学, 大学院・理学研究科, 准教授 (40143250)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: マウス胚 / 肺 / 唾液腺 / 分枝形態形成 / 上皮 / 自己分泌 / 成長因子 / リペラント / 上皮組織 / 自己分泌型成長因子 / 反発作用

Research Abstract

The present study focused on the molecules that affected the epithelium via autocrine signaling during branching morphogenesis of embryonic mouse lung and salivary gland. It was revealed that branching morphogenesis of lung epithelium was driven by autocrine FGF1 and FGF9 upregulated by exogenous FGF10, and that there worked repulsion between salivary epithelial lobules.

Research Products

• [Journal Article] Autocrine growth factors are involved in branching morphogenesis of mouse lung epithelium (2013)
  • Author(s): Okada K., Noda M. and Nogawa H.
  • Journal Title: Zoological Science Volume: Vol.30 Issue: 1 Pages: 1-6
  • DOI: 10.2108/zsj.30.1
  • NAID: 40019540372
  • Peer Reviewed
• [Journal Article] Evidence of interlobular repulsion during branching morphogenesis in mouse salivary glands (2010)
  • Author(s): Okamoto K., Kikuchi-Handa T. and Nogawa H.
  • Journal Title: Developmental Dynamics Volume: Vol.239 Issue: 8 Pages: 2208-2218
  • DOI: 10.1002/dvdy.22354
  • Peer Reviewed
• [Journal Article] Evidence of interlobular repulsion during branching morphogenesis in mouse salivary glands (2010)
  • Author(s): Okamoto K, Kikuchi-Handa T., Togawa H.
  • Journal Title: Developmental Dynamics Volume: 239 Pages: 2208-2218
  • Peer Reviewed
• [Presentation] マウス胚肺上皮の分枝形態形成への自己分泌型成長因子の関与 (2012)
  • Author(s): 岡田貴美子,後藤麻美,野田真継,野川宏幸
  • Organizer: 日本動物学会第83回大会,大阪大学豊中キャンパス
  • Year and Date: 2012-09-13
• [Presentation] マウス胚肺上皮の分枝形態形成への自己分泌型成長因子の関与 (2012)
  • Author(s): 岡田貴美子，後藤麻美，野田真継，野川宏幸
  • Organizer: 日本動物学会第83回大会
  • Place of Presentation: 大阪大学豊中キャンパス
• [Presentation] マウス胚唾液腺の分枝パターンを規定する上皮間の反発作用 (2011)
  • Author(s): 野川宏幸
  • Organizer: 第53回歯科基礎医学会学術大会,長良川国際会議場
  • Year and Date: 2011-10-02
• [Presentation] マウス胚唾液腺の分枝パターンを規定する上皮間の反発作用 (2011)
  • Author(s): 野川宏幸
  • Organizer: 第53回歯科基礎医学会学術大会
  • Place of Presentation: 長良川国際会議場(岐阜県)(招待講演)
  • Year and Date: 2011-10-02
• [Presentation] マウス唾液腺の分枝形態形成における上皮間の反発作用 (2010)
  • Author(s): 岡本克也,半田智美,野川宏幸
  • Organizer: 日本動物学会第81回大会,東京大学教養学部
  • Year and Date: 2010-09-25
• [Presentation] マウス唾液腺の分枝形態形成における上皮間の反発作用 (2010)
  • Author(s): 岡本克也, 半田智美, 野川宏幸
  • Organizer: 日本動物学会第81回大会
  • Place of Presentation: 東京大学教養学部
  • Year and Date: 2010-09-25
• [Remarks]
  • URL: http://life.s.chiba-u.jp/nogawa/lab/
• [Remarks]
  • URL: http://life.s.chiba-u.jp/nogawa/lab/
• [Remarks]
  • URL: http://life.s.chiba-u.jp/nogawa/lab/