Roles of autocrine signaling molecules in epithelial branching morphogenesis
| Project/Area Number |
22570059
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Morphology/Structure
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| Research Institution | Chiba University |
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Principal Investigator |
NOGAWA Hiroyuki 千葉大学, 大学院・理学研究科, 准教授 (40143250)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | マウス胚 / 肺 / 唾液腺 / 分枝形態形成 / 上皮 / 自己分泌 / 成長因子 / リペラント / 上皮組織 / 自己分泌型成長因子 / 反発作用 |
|---|
| Research Abstract |
The present study focused on the molecules that affected the epithelium via autocrine signaling during branching morphogenesis of embryonic mouse lung and salivary gland. It was revealed that branching morphogenesis of lung epithelium was driven by autocrine FGF1 and FGF9 upregulated by exogenous FGF10, and that there worked repulsion between salivary epithelial lobules.
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Report
(4 results)
Research Products
(12 results)
