| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
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| Research Abstract |
The present study provides the first evidence that mRNAs of eight GLUT isoforms are expressed in the stria vascularis and the spiral ligament. These GLUT isoforms are suspected to involve in the high metabolic activity of the stria vascularis, and to play specific roles in maintenance of cochlear glucose homeostasis. Among these isoforms, GLUT1, -4 and -10 proteins were expressed in the strial basal cells. These findingsvalidate the transcellular glucose pathway from perilymph to intrastrial space via the basal cell layer. We also demonstrated that GLUT13 (HMIT) was expressed in the strial marginal cells, and speculate that HMIT in the marginal cells may be involved in PI synthesis, osmoregulation, and pH homeostasis of cochlear fluids.
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