The possibleprincipal function of neurohypophysial hormones

• Project/Area Number: 22570065
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Morphology/Structure
• Research Institution: Okayama University
• Principal Investigator: SAKAMOTO Tatsuya 岡山大学, 大学院・自然科学研究科, 教授 (10294480)
• Co-Investigator(Kenkyū-buntansha): OGOSHI Maho 岡山大学, 自然科学研究科, 助教 (00527997) ; SAKAMOTO Hirotaka 岡山大学, 自然科学研究科, 准教授 (20363971) ; TAKAHASHI Hideya 岡山大学, 理学部, 助教 (50627635)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 比較内分泌 / 環境適応 / バソトシン / イソトシン / トビハゼ / 環境 / 神経行動 / 脳 / 国際研究者交流 / アメリカ合衆国 / ニュージーランド

Research Abstract

Acclimation from marine to dilute environments constitutes among the most dramatic evolutionary transitions in the history of life. Such adaptations have evolved in multiple lineages, but studies of the mechanisms are limited to those using evolutionarily advanced Deuterostome (chordates) and Ecdysozoa (crustaceans). Here we examined the body-fluid homeostasis in the advanced Lophotrochozoa/mollusc, the other unexplored taxa, and its possible regulations byvasopressin/oxytocin superfamily peptides known to be implicated in fluid homeostasis in Chordata and Arthropoda. The hemolymph osmotic and ionic status in the euryhaline cephalopod (Octopus ocellatus) following transfer from normal seawater (30 ppt) to low (20 ppt) salinity indicate the hyperosmo- and hyperiono-regulatory abilities for more than 1 week, as in crustaceans and teleost fish. While ventilation frequency decreased by 1 day, Na+/K+-ATPase activity, which has been implicated in ion transport generally, was induced in two of the eight posterior gills after 1 week. Furthermore, the octopuses were intravenously injected with 1 or 100 ng/g octopressin or cephalotocin, cephalopod vasopressin/oxytocin orthologs. After 1 day, octopressin, not cephalotocin, decreased the hemolymph osmolality and Ca concentrations as well as urinary Na concentrations. These data provide evidence for convergent evolution in the hyper-ionoregulatory mechanisms and the coordination by conserved molecules.

Research Products

• [Journal Article] The role of 'mineralocorticoids' in teleost fish: Relative importance of glucocorticoid signaling in the osmoregulation and central actions of mineralocorticoid receptor (2013)
  • Author(s): H. Takahashi, T. Sakamoto
  • Journal Title: Gen Comp Endocrinol Volume: 181 Pages: 223-228
  • Peer Reviewed
• [Journal Article] In vitro effects of the prolactin, growth hormone and somatolactin on cell turnover in fish esophagus: possible mode of opposite osmoregulatory actions of prolactin and growth hormone (2013)
  • Author(s): H. Takahashi, H. Kudose, C. Takagi, S. Moriyama, T. Sakamoto
  • Journal Title: Prolactin Pages: 21-34
  • DOI: 10.5772/53867
  • ISBN: 9789535109433
  • Peer Reviewed
• [Journal Article] Static and dynamic hypergravity responses of osteoblasts and osteoclasts in medaka scales (2013)
  • Author(s): S. Yano, K. Kitamura, Y. Satoh, M. Nakano, A. Hattori, T. Sekiguchi, M. Ikegame, H. Nakashima, K. Omori, K. Hayakawa, A. Chiba, Y. Sasayama, S. Ejiri, Y. Mikuni-Takagaki, H. Mishima, H. Funahashi, T. Sakamoto, N. Suzuki
  • Journal Title: Zool Sci Volume: 30 Pages: 217-223
  • NAID: 120005285927
  • Peer Reviewed
• [Journal Article] H. Sakamoto,H. Takahashi, K. Matsuda, M. Nishi, K. Takanami, M. Ogoshi, T. Sakamoto, M. Kawata (2012)
  • Author(s): Rapid signaling of steroid hormones in the vertebrate nervous system
  • Journal Title: Front Biosci Volume: 17 Pages: 996-1019
  • Peer Reviewed
• [Journal Article] Three-dimensional evaluation of the spinal local neural network revealed by the high-voltage electron microscopy: a double immunohistochemical study (2012)
  • Author(s): T. Oti, K. Satoh, K. Saito, K. Murata, M. Kawata, T. Sakamoto, H. Sakamoto
  • Journal Title: Histochem Cell Biol Volume: 138 Issue: 4 Pages: 693-697
  • DOI: 10.1007/s00418-012-0976-6
  • Peer Reviewed
• [Journal Article] Growth, energetics and the cortisol-hepatic glucocorticoid receptor axis of medaka (Oryzias latipes) in various salinities. (2012)
  • Author(s): M. Ogoshi, K. Kato, H. Takahashi, T. Ikeuchi, T. Abe, T. Sakamoto
  • Journal Title: Gen Comp Endocrinol Volume: 178 Issue: 2 Pages: 175-179
  • DOI: 10.1016/j.ygcen.2012.05.001
  • Peer Reviewed
• [Journal Article] Cloning of two members of the calcitonin-family receptors from stingray, Dasyatis akajei: Possible physiological roles of the calcitonin family in osmoregulation (2012)
  • Author(s): N. Suzuki, T. Sekiguchi, H. Satake, K. Kato, Y. Nishiyama, H. Takahashi, J.A. Danks, T.J. Martin, A. Hattori, M. Nakano, M. Kakikawa, S. Yamada, M. Ogoshi, S. Hyodo, Y. Yamaguchi, V.S. Chowdhury, K. Hayakawa, H. Funahashi, T. Sakamoto, Y. Sasayama
  • Journal Title: Gene Volume: 499 Pages: 326-331
  • NAID: 120004140850
  • Peer Reviewed
• [Journal Article] Hemolymph osmotic, ionic status and branchial Na+/K+-ATPase activity under varying environmental conditions in the intertidal grapsid crab (2012)
  • Author(s): Gaetice depressus. T. Nanba, H. Takahashi, T. Abe, W. Godo, M. Ogoshi, H. Sakamoto, N. Tsutsui, T. Sakamoto
  • Journal Title: Int Aquat Res Volume: 4 Pages: 1-12
  • Peer Reviewed
• [Journal Article] Prostaglandin E2 increases both osteoblastic and osteoclastic activities in the scales of goldfish and participates in the calcium metabolism in goldfish (2012)
  • Author(s): Omori, K., Wada, S., Maruyama, Y., Hattori, A., Kitamura, K., Sato, Y., Nara, M., Funahashi, H., Yachiguchi, K., Hayakawa, K., Endo, M., Kusakari, R., Yano, S., Srivastav, A.K., Kusui, T., Ejiri, S., Chen, W., Tabuchi, Y., Furusawa, Y., Kondo, T., Sasayama, Y. Nishiuchi, T., Nakano, M., Sakamoto, T. and Suzuki, N.
  • Journal Title: Zool. Sci Volume: 29 Issue: 8 Pages: 499-504
  • DOI: 10.2108/zsj.29.499
  • Peer Reviewed
• [Journal Article] Morphological responses of mitochondria-rich cells to hypersaline environment in the australian mudskipper, Periophthalmus minutus (2012)
  • Author(s): N. Itoki, T. Sakamoto, M. Hayashi, T. Takeda, A. Ishimatsu
  • Journal Title: Zool Sci Volume: 29 Pages: 444-449
  • NAID: 40019342110
  • Peer Reviewed
• [Journal Article] Rapid signaling of steroid hormones in the vertebrate nervous system (2012)
  • Author(s): H. Sakamoto
  • Journal Title: Front Biosci Volume: 17 Pages: 996-1019
  • Peer Reviewed
• [Journal Article] Corticosteroids stimulate the amphibious behavior in mudskipper: potential role of mineralocorticoid receptors in teleost fish (2011)
  • Author(s): T. Sakamoto, C. Mori, S. Minami, H. Takahashi, T. Abe, D. Ojima, M. Ogoshi, H. Sakamoto
  • Journal Title: Physiol Behav. Volume: 104 Pages: 923-928
  • Peer Reviewed
• [Journal Article] Dual in vitro effects of cortisol on cell turnover in the medaka esophagus via the glucocorticoid receptor (2011)
  • Author(s): C. Takagi, H. Takahashi, H. Kudose, K. Kato, T. Sakamoto
  • Journal Title: Life Sci Volume: 88 Pages: 239-245
  • Peer Reviewed
• [Journal Article] Embryonic development and larval behavior of the kissing loach (Parabotia curta): adaptations to an ephemeral, hypoxic environment (2011)
  • Author(s): T. Abe, T. Sakamoto
  • Journal Title: Ichthyol Res Volume: 58 Pages: 238-244
  • NAID: 10029296075
  • Peer Reviewed
• [Journal Article] Isolation and characterisation of prolactin-releasing peptide in chicks and its effect on prolactin release and feeding behaviour (2011)
  • Author(s): T. Tachibana, S. Moriyama, A. Takahashi, A. Tsukada, A. Oda, S. Takeuchi, T. Sakamoto
  • Journal Title: J Neuroendocrinol Volume: 23 Pages: 74-81
  • Peer Reviewed
• [Journal Article] Corticosteroids stimulate the amphibious behavior in mudskipper: Potential role of mineralocorticoid receptors in teleost fish (2011)
  • Author(s): Sakamoto, T.
  • Journal Title: Physiol Behav Volume: 104 Pages: 923-8
  • Peer Reviewed
• [Journal Article] Dual in vitro effects of cortisol on cell turnover in the medaka esophagus via the glucocorticoid receptor (2011)
  • Author(s): Takagi, C.
  • Journal Title: Life Sci Volume: 88 Pages: 239-45
  • Peer Reviewed
• [Journal Article] Detection and activity of iodine-131 in brown algae collected in the Japanese coastal areas (2010)
  • Author(s): T. Morita, K. Niwa, K. Fujimoto, H. Kasai, H. Yamada, K. Nishiutch, T. Sakamoto, W. Godo, S. Taino, Y. Hayashi, K. Takeno, T. Nishigaki, K. Fujiwara, H. Aratake, S. Kamonoshita, H. Hashimoto, T. Kobayashi, S. Otosaka, T. Imanaka
  • Journal Title: Sci Total Environ Volume: 408 Pages: 3443-3447
  • Peer Reviewed
• [Journal Article] Detection and activity of iodine-131 in brown algae collected in the Japanese coastal areas (2010)
  • Author(s): Morita, T.
  • Journal Title: Sci Total Environ Volume: 408 Pages: 3443-7
  • Peer Reviewed
• [Journal Article] Comparative and general aspects of calcium homeostasis and its hormonal regulations
  • Author(s): N. Suzuki, T. Sakamoto
  • Journal Title: Zool Sci. Virtual Issue, Evolution of calcium homeostasis and its hormonal regulation in vertebrates
  • URL: http://www.zoology.or.jp/news/index.asp?patten_cd=12&page_no=541
  • Peer Reviewed
• [Presentation] Mineralocorticoid may not be "mineralocorticoid" in fish (2012)
  • Author(s): H. Takahashi,T. Sakamoto
  • Organizer: 国際学会招待講演 7th Asia and Oceania Society for Comparative Endocrinology Congress
  • Year and Date: 2012-03-04
• [Presentation] MINERALOCORTICOID MAY NOT BE "MINERALOCORTICOID" IN FISH (2012)
  • Author(s): Sakamoto T.
  • Organizer: 7th Asia and Oceania Society for Comparative Endocrinology (AOSCE) Congress
  • Place of Presentation: Sunway, Malaysia(招待講演)
  • Year and Date: 2012-03-04
• [Presentation] Updated functions of glucocorticoid and mineralocorticoid in teleost fish (2012)
  • Author(s): H. Takahashi,T. Sakamoto
  • Organizer: 国際シンポジウム招待講演 Edwin W. Pauley Summer Program in Marine Biology "Integrative, Experimental and environmental physiology of marine organisms
• [Presentation] Current studies at Ushimado Marine Institute (2011)
  • Author(s): T. Sakamoto
  • Organizer: 国際シンポジウム招待講演 Practical Environmental Education Program to Construct a Cyclical Environmental Society "Water environment specialists incubated from the sunny country"
• [Presentation] Osmoregulation "Under Water" (2010)
  • Author(s): 坂本竜哉
  • Organizer: 新潟大学理学部 自然環境科学科 環境生物学大講座 臨時セミナー
  • Place of Presentation: 新潟大学理学部大会議室(新潟)
  • Year and Date: 2010-11-18
• [Presentation] Updated functions of glucocorticoid and mineralocorticoid in teleost fish
  • Author(s): H. Takahashi
  • Organizer: Edwin W. Pauley Summer Program in Marine Biology
  • Place of Presentation: USA
  • Invited
• [Book] Prolactin (2013)
  • Author(s): H. Takahashi
  • Total Pages: 230
  • Publisher: InTech
• [Book] Evolution of calcium homeostasis and its hormonal regulation in vertebrates (2012)
  • Author(s): N. Suzuki
  • Publisher: Zool Sci
• [Book] Evolution of calcium homeostasis and its hormonal regulation in vertebrates (2012)
  • Author(s): Nobuo Suzuki
  • Publisher: UniBio Press(印刷中)
• [Book] 第2版『現代生物学入門』 (2011)
  • Author(s): 岡山大学生物学教科書作成グループ編
  • Total Pages: 186
  • Publisher: 岡山大学出版会
• [Book] Evolution of calcium homeostasis and its hormonal regulation in vertebrates
  • Author(s): N. Suzuki, T. Sakamoto
  • Publisher: Zool Sci. Virtual Issue Theme 2