| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
Immunohistochemical analysis using medaka arylsulfatase (Ars) antibodies revealed that extracellular distribution and colocalization with extracellular matrices of ArsA and ArsB were observed only in the restricted regions, such as on the luminal side of blood vessels, and in the cerebral ventricle, though they were ubiquitously synthesized. Knockdown analysis of Arses by using morpholino antisense oligonucleotides showed that ArsB is involved in morphogenesis during medaka development. These results suggest the possibility that the Arses function as novel components of extracellular matrices by constructing extracellular environment through circulatory systems during development.
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