| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
ANP receptor, which belongs to a member of guanylyl cyclase (GCase) receptor family,plays a key role in the regulation of blood pressure and body fluid balance in our body.The mechanisms "how the GCase receptor recognizes hormone" and "how the receptortransmits the hormone-binding signal to its intracellular domain” are still unknown.To elucidate the mechanisms, we performed x-ray crystallography of the ANP receptorextracellular domain complexed with ligands and kinetics experiments of the receptor.
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