| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
(1) Functional analysis of FABP5 in nuclear receptor PPAR signaling in carcinogenesis or metastasis: I have found that nuclear receptor PPAR target gene, FABP5, is up-regulated in human malignant prostate cancer cellsand that is localized into the nucleus in a ligand (fatty acid)-dependent manner.
(2)Functional analysis of FABP6 in nuclear receptor FXR signaling: I have identified novel miRNAs and their target genes that were activated by the FXR agonist. Furthermore, I have demonstrated that a variant protein for FABP6, called FABP6-L/IBABP-L, has exhibited anti-apoptotic activity in the presence of bile acid in colorectal cancer cells.
(3) Activation mechanisms of FABP5 gene expression: I have found that DNA methylation status of FABP5 gene isolated from PC-3 is much more demethylated compared withthat of the gene from PNT-2.
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