Studies on the molecular behavior of the 26S proteasome by a low resolution structure analysis
| Project/Area Number |
22570113
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Structural biochemistry
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | X線結晶構造解析 / プロテアソーム / 分子動態 / Ｘ線結晶構造解析 / 結晶構造解析 / 脱ユビキチン化酵素 |
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| Research Abstract |
In this study, the 26S proteasome, whole particle, was investigated at the
(1) purification from gene-modified yeast and crystallization
and (2) small-angle scattering analysis for clarifying a shape of the whole particle and phase calculation in a crystallographic electron density map by the shape function.
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Report
(4 results)
Research Products
(25 results)
