| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
The aim of this study was to identify RNA molecules involved in chromatin regulation by focusing on RNA-binding histone chaperone Nucleophosmin/B23. We found that B23 was recruited to the rRNA gene loci by using its RNA binding activity. In addition, we clarified the molecular mechanism by which B23 binds to specific RNA target. Furthermore, we identified RNA molecules specifically bound by B23 in vivo. This study will contribute to understand the regulation mechanism of chromatin structure.
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