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Studies on the mechanisms of functional differentiation of taste bud cells

Research Project

Project/Area Number 22570134
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Functional biochemistry
Research InstitutionThe University of Tokyo

Principal Investigator

EMORI Yasufumi  東京大学, 大学院・理学系研究科, 准教授 (60160389)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords味覚 / 味蕾 / 分化 / 転写因子
Research Abstract

Taste bud cells, belonging to epithelialcelllineage, play essential roles in taste perception, and continuously turnover even in the adult stage. Many aspects about their differentiation are unknown, then, in this study, I searched for transcription factors expressed in taste bud cells, and investigated the expression and function of these factors. As a result, I found two factors of MEF2 and NFAT families, and found that they begin to express concomitantly with the differentiation of type II cells which have main taste sensations. In addition, the regulatory process is related to the calcium signaling of taste transduction.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (5 results)

All 2012 2011 2010

All Presentation (4 results) Book (1 results)

  • [Presentation] Lifespans of type II and type III cells of mouse taste buds in circumvallate papillae.2011

    • Author(s)
      Togawa H., Asano-Miyoshi M., and Emori Y.
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜、横浜市
    • Year and Date
      2011-12-13
    • Related Report
      2012 Final Research Report
  • [Presentation] Lifespans of type II and type III cells of mouse taste buds in circumval late papillae2011

    • Author(s)
      Haruna Togawa, Misaki Asao-Miyoshi, Yasufumi Emori
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜市、パシフィコ横浜
    • Year and Date
      2011-12-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] ショウジョウバエの二つの組織普遍的カ ルパイン(カルパインAとB)の酵素学的性質の類似性と相違点。2010

    • Author(s)
      東海林保志、小田有沙、榎森康文
    • Organizer
      第33回日本分子生物学会年会、第83回日本生化学会大会、共同大会
    • Place of Presentation
      神戸ポートアイランド、神戸市
    • Year and Date
      2010-12-10
    • Related Report
      2012 Final Research Report
  • [Presentation] ショウジョウバエの二つの組織普遍的カルパイン(カルパインAとB)の酵素学的性質の類似点と相違点2010

    • Author(s)
      東海林保志、小田有紗、榎森康文
    • Organizer
      第83回日本生化学会大会・第33回日本分子生物学会年会・合同大会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2010-12-10
    • Related Report
      2010 Annual Research Report
  • [Book] シグナル伝達キーワード事典2012

    • Author(s)
      榎森康文
    • Publisher
      羊土社
    • Related Report
      2012 Annual Research Report 2012 Final Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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