Analysis of physiological regulation of tRNA from the view of its intracellular dynamics.
| Project/Area Number |
22570139
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional biochemistry
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| Research Institution | Nagoya University |
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Principal Investigator |
YOSHIHISA Tohru 名古屋大学, 物質科学国際研究センター, 准教授 (60212312)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | tRNA / 細胞内動態 / tRNAリガーゼ / スプライシング / tRNA切断 / 出芽酵母 / 細胞内動熊 |
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| Research Abstract |
Recently, many researchers are interested in various regulations of tRNA function in the cytoplasm and in tRNA fragments as signaling molecules. In this project, I performed molecular genetical analyses with budding yeast as a model organism to understand relation between tRNA fragmentation in the cytoplasm and the yeast splicing system, difference in stability between mature tRNAs and introns produced by cytoplasmic splicing, and mechanism of nuclear import and export of tRNAs, which determines nuclear-cytoplasmic balance of tRNAs.
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Report
(4 results)
Research Products
(28 results)
