| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Research Abstract |
To elucidate the molecular mechanisms by which basement membrane laminins regulate various cellular functions such as growth, differentiation, survival and migration, we focused on cell adhesion complexes based on laminin -binding integrins. As a result of the proteomic analyses of the complexes, we found the possibility that tetraspanin-enriched structures are involved in the regulation of the rear-end retraction in migrating cells on laminins.
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