| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
We previously generated NDRG4-deficient mice that exhibit spatial learning deficits and vulnerabilities to cerebral ischemia. This study revealed that NDRG4 contributed to the maintenance of intracerebral BDNF levels within the normal range, which is necessary for the normal functions of neuronal cells. We identified NDRG4-binding proteins, which also interacted with NDRG1-NDRG3. NDRG family proteins may regulate cell activities through the functions of the binding proteins.
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