Regulatory mechanism of Topoisomerase1 by small RNA molecules which leads genomic instability
| Project/Area Number |
22570169
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Molecular biology
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| Research Institution | Kyoto University |
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Principal Investigator |
KOBAYASHI Maki 京都大学, 大学院・医学研究科, 准教授 (20400690)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | non-B DNA / AID / 免疫グロブリン / miRNA / 免疫グロブリン遺伝子 / DNA切断 / Non-B DNA / Topoisomerase1 / RNA編集 / 翻訳調節 |
|---|
| Research Abstract |
The molecular mechanism which suppresses Topoisomerase1 (Top1) translation in AID-dependent manner was analyzed. Involvement of miRNA, HuR and Ago2, and Ago2-binding sequence in Top1 mRNA have been realized. The putative miRNA which binds to Top1 mRNA AID-dependently will be identified very soon.
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Report
(4 results)
Research Products
(25 results)
