Analysis of gene transcription start regulatory mechanism by crosstalk between histone modifications
| Project/Area Number |
22570173
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Molecular biology
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| Research Institution | Nagasaki University |
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Principal Investigator |
NAKAGAWA Takeya 長崎大学, 大学院・医歯薬学総合研究科, 助教 (50363502)
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| Co-Investigator(Kenkyū-buntansha) |
ITO Takashi 長崎大学, 医歯(薬)学総合研究科, 教授 (90306275)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 転写 / 遺伝子転写制御 / ヒストン修飾 / クロストーク |
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| Research Abstract |
In the present study, I investigated mechanism of transcriptional regulation by crosstalk between two histone modifications. We have already revealed the crosstalk between ubiquitylation of H2AK119 and methylation of H3K4. In this study ,we obtained a result that indicate the involvement of hisotne H4 acetylation to this crosstalk.
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Report
(4 results)
Research Products
(2 results)
