Analysis of gene transcription start regulatory mechanism by crosstalk between histone modifications

Research Project

Project/Area Number	22570173
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Molecular biology
Research Institution	Nagasaki University
Principal Investigator	NAKAGAWA Takeya 長崎大学, 大学院・医歯薬学総合研究科, 助教 (50363502)
Co-Investigator(Kenkyū-buntansha)	ITO Takashi 長崎大学, 医歯(薬)学総合研究科, 教授 (90306275)
Project Period (FY)	2010 – 2012
Project Status	Completed (Fiscal Year 2012)
Budget Amount *help	¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000) Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	転写 / 遺伝子転写制御 / ヒストン修飾 / クロストーク
Research Abstract	In the present study, I investigated mechanism of transcriptional regulation by crosstalk between two histone modifications. We have already revealed the crosstalk between ubiquitylation of H2AK119 and methylation of H3K4. In this study ,we obtained a result that indicate the involvement of hisotne H4 acetylation to this crosstalk.

Report

(4 results)