The mechanisms of histone balance control coupling with chromatin assembly
| Project/Area Number |
22570174
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Molecular biology
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| Research Institution | Nagoya City University |
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Principal Investigator |
TAGAMI Hideaki 名古屋市立大学, 大学院・システム自然科学研究科, 准教授 (70273216)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | ヒストン / クロマチン構造 / ヒストン複合体 / Mlo2 / Cia1 / クロマチン形成 / 可溶性ヒストン / 可溶性ヒストン複合体 / クロマチンダイナミクス / HiTAP1 / ヒストンH3/H4 / エピジェネティクス |
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| Research Abstract |
Chromatin assembly is controlled strictly in association with genome integrity. In this study, in order to elucidate the molecular basis of histone balance control system, we purified the soluble histone complexes as reaction intermediates. We identified a novel soluble H3 binding factor in fission yeast. Further biochemical and genetic analyses suggest a new aspect for soluble H3 level control and cell growth.
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Report
(4 results)
Research Products
(16 results)
