Defining the molecular mechanism of checkpoint recovery from DNA damage.
| Project/Area Number |
22570180
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cell biology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
KONISHI Akimitsu 東京医科歯科大学, 難治疾患研究所, 講師 (50381877)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 細胞周期 / DNA損傷チェックポイント / 分子生物学 / ケミカルスクリーニング / 癌抑制 / DNA損傷 |
|---|
| Research Abstract |
This project aims to understand how cells recover from DNA damage and to define the therapeutic potential for anti-cancer drug. We identified the inhibitors for the DNA damage recovery processes and revealed their molecular mechanism. Moreover, our newly identified drugs could inhibit the tumor cell growth. These findings will contribute to develop a novel strategy against cancer.
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Report
(4 results)
Research Products
(19 results)
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[Journal Article] Involvement of JNK in the regulation of autophagic cell death2010
Author(s)
Shimizu, S., Konishi, A., Nishida, Y., Mizuta, T., Nishina, H., Yamamoto, A., and Tsujimoto, Y
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Journal Title
Oncogene 29
Pages: 2070-2082
Related Report
Peer Reviewed
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