Analysis of physiological role of SVIL for cytokinesis
Project/Area Number |
22570182
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Cell biology
|
Research Institution | Nagoya University |
Principal Investigator |
SENGA Takeshi 名古屋大学, 医学系研究科, 准教授 (80419431)
|
Project Period (FY) |
2010 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 細胞質分裂 / SVIL / PLK1 / ミオシン / Central spindle / セントラルスピンドル / 中央体 / 収縮環 / リン酸化 / Central Spindle / Midbody / モータータンパク質 / Supervillin |
Research Abstract |
We found that Supervillin (SVIL) was localized to the central spindle during cytokinesis. The localization was dependent on the phosphorylation of Ser238 of SVIL. Expression ofSVIL with the substitution of Ser238 (SVIL-S238A) to alanine inhibited progression of cytokinesis. Furthermore, aberrant ingression of cytokinetic furrow was observed in SVIL-S238A expressing cells. Our results show that phosphorylation of SVIL is essential for the completion of cytokinesis.
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Report
(4 results)
Research Products
(16 results)
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[Journal Article] ALX1 induces Snail expression to promote epithelial to mesenchymal transition and invasion of ovarian cancer cells.2013
Author(s)
Yuan H, Kajiyama H, Ito S, Yoshikawa N, Hyodo T, Asano E, Hasegawa H, Maeda M, Shibata K, Hamaguchi M, Kikkawa F, Senga T
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Journal Title
Cancer Research
Volume: 73
Pages: 1581-90
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Peer Reviewed
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[Journal Article] ARHGAP18, a GTPase-activating protein for RhoA, controls cell shape, spreading, and motility.2011
Author(s)
Maeda M, Hasegawa H, Hyodo T, Ito S, Asano E, Yuang H, Funasaka K, Shimokata K, Hasegawa Y, Hamaguchi M, Senga T
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Journal Title
Mol Biol Cell
Volume: 22(20)
Pages: 3840-52
Related Report
Peer Reviewed
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