| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
We analyzed cross talk between cell cycle inhibition and autophagy through a leukemia-associated MLF1-CSN-COP1-p53 pathway, in which the center regulator is the E3 ubiquitin ligase COP1. We found that COP1 markedly inhibits DNA damage-induced (UV irradiation) autophagy leading to tumorigenesis and interacts with FIP200, an autophagy-promoting factor. These data suggest that the MLF1-CSN-COP1-p53 pathway contributes to tumorigenesis by controlling the regulation between cell cycle and autophagy.
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