Live imaging analysis for the relationship between morphology and function in the ER membrane
| Project/Area Number |
22570194
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cell biology
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
KUROKAWA Kazuo 独立行政法人理化学研究所, 中野生体膜研究室, 専任研究員 (40333504)
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| Co-Investigator(Renkei-kenkyūsha) |
岡本 美智代
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | ERES / COPII / membrane curvature / 小胞体 / 膜曲率 |
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| Research Abstract |
We examined ERES localization within the peripheral ER, finding that ERES localize on high-curvature ER domains where curvature-stabilizing protein Rtn1 is present. In mutant cells having fewer high-curvature ER domains, ERES accumulate at the remaining high-curvature ER domains on the edge of expanded ER sheets. We propose that membrane curvature is a key geometric feature for the regulation of ERES localization.
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Report
(4 results)
Research Products
(27 results)
