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Mechanism of the reorganization of developmental gene regulatory network

Research Project

Project/Area Number 22570198
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Developmental biology
Research InstitutionTohoku University

Principal Investigator

MINOKAWA Takuya  東北大学, 大学院・生命科学研究科, 准教授 (60400305)

Research Collaborator YAMAZAKI Atsuko  東北大学, 大学院・生命科学研究科, 日本学術振興会特別研究員(PD)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords進化発生 / 発生調節遺伝子 / 遺伝子ネットワーク / 水腔動物 / 棘皮動物 / 進化
Research Abstract

The purpose of the present research is to elucidate the molecular mechanism responsible for the gene regulatory network (GRN) reorganization during animal evolution. Various species belonging to the ambulacraria have been used as model species. Especially, we are interested in tbr expression in the apical organ of the sand dollar Peronella japonica. We confirmed that P. japonica is an exceptional echinoid species that possesses tbr expression in the apical organ. The cis-regulatory analysis for P. japonica tbr revealed that approximately 1 kb upstream sequence of the coding region suffices to activate transcription of a reporter gene in the broad regions containing mesoderm and ectoderm.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (25 results)

All 2012 2011 2010 Other

All Journal Article (5 results) (of which Peer Reviewed: 2 results) Presentation (16 results) Remarks (4 results)

  • [Journal Article] "Micromere" formation and expression of endomesoderm regulatory genes during embryogenesis of the primitive echinoid Prionocidaris baculosa. Development2012

    • Author(s)
      Yamazaki, A., Y. Kidachi and T. Minokawa
    • Journal Title

      Growth and Differentiation

      Volume: 54 Pages: 566-578

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 青森県陸奥湾における半索動物ミサキギボシムシBalanoglossus misakiensis Kuwano,1902の初記録2012

    • Author(s)
      阿部広和、鷲尾正彦、山嵜敦子、美濃川拓哉、西川輝昭
    • Journal Title

      青森自然誌研究

      Volume: 17 Pages: 25-27

    • NAID

      40019303604

    • Related Report
      2012 Final Research Report
  • [Journal Article] 'Micromere' formation and expression of endomesoderm regulatory genes during embryogenesis of the primitive echinoid Prionocidaris baculosa.2012

    • Author(s)
      A. Yamazaki, Y. Kidachi, T. Minokawa
    • Journal Title

      Dev. Growth Differ.

      Volume: 54 Issue: 5 Pages: 566-578

    • DOI

      10.1111/j.1440-169x.2012.01360.x

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 青森県陸奥湾における半索動物ミサキギボシムシBalanoglossus misakiensis Kuwano, 1902の初記録2012

    • Author(s)
      阿部広和
    • Journal Title

      青森自然誌研究

      Volume: 17 Pages: 25-27

    • Related Report
      2012 Annual Research Report
  • [Journal Article] 青森県陸奥湾における半索動物ミサキギボシムシBalanoglossus misakiensis Kuwano, 1902の初記録2012

    • Author(s)
      阿部広和、鷲尾正彦、山嵜敦子、美濃川拓哉、西川輝昭
    • Journal Title

      青森自然史研究

      Volume: 17(印刷中)

    • NAID

      40019303604

    • Related Report
      2011 Annual Research Report
  • [Presentation] ウニ類における「小割球」の進化2012

    • Author(s)
      山嵜敦子、美濃川拓哉
    • Organizer
      第9回棘皮動物研究集会
    • Place of Presentation
      東北大学
    • Year and Date
      2012-12-08
    • Related Report
      2012 Final Research Report
  • [Presentation] 原始的ウニ・キダリスの間充織特異化メカニズム2012

    • Author(s)
      山嵜敦子、木立由美、美濃川拓哉
    • Organizer
      日本動物学会第83回大阪大会
    • Place of Presentation
      大阪大学
    • Year and Date
      2012-09-22
    • Related Report
      2012 Final Research Report
  • [Presentation] Evolution of the micromeres in echinoids2011

    • Author(s)
      Takuya Minokawa
    • Organizer
      Commemorative of 27^<th> International Prize for Biology
    • Place of Presentation
      京都ガーデンパレス
    • Year and Date
      2011-11-30
    • Related Report
      2012 Final Research Report
  • [Presentation] Evolution of the micromeres in echinoids2011

    • Author(s)
      Takuya Minokawa
    • Organizer
      Commemorative Symposium for the 27^<th> International Prize for Biology "Genetic Regulation of Development"
    • Place of Presentation
      京都ガーデンパレス
    • Year and Date
      2011-11-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] ウニ類の"祖先型"幼生骨片形成機構2011

    • Author(s)
      山嵜敦子、木立由美、美濃川拓哉
    • Organizer
      日本動物学会第82回旭川大会
    • Place of Presentation
      旭川市大雪クリスタルホール
    • Year and Date
      2011-09-22
    • Related Report
      2012 Final Research Report
  • [Presentation] ウニにおける第一卵割面と幼生前後軸の関係の多様性2011

    • Author(s)
      美濃川拓哉、雨宮昭南
    • Organizer
      日本動物学会第82回旭川大会
    • Place of Presentation
      旭川市大雪クリスタルホール
    • Year and Date
      2011-09-22
    • Related Report
      2012 Final Research Report
  • [Presentation] ウニ類の「祖先型」幼生骨片形成機構2011

    • Author(s)
      山嵜敦子、木立由美、美濃川拓哉
    • Organizer
      日本動物学会第82回大会
    • Place of Presentation
      旭川市大雪クリスタルホール
    • Year and Date
      2011-09-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] ウニにおける第一卵割面と幼生前後軸の関係の多様性2011

    • Author(s)
      美濃川拓哉、雨宮昭南
    • Organizer
      日本動物学会第82回大会
    • Place of Presentation
      旭川市大雪クリスタルホール
    • Year and Date
      2011-09-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] 青森湾に生息するギボシムシ類(半索動物腸鰓綱)2011

    • Author(s)
      浦田慎、美濃川拓哉、西川輝昭、阿部広和、鷲尾正彦
    • Organizer
      日本動物学会第82回旭川大会
    • Place of Presentation
      旭川市大雪クリスタルホール
    • Year and Date
      2011-09-21
    • Related Report
      2012 Final Research Report
  • [Presentation] 青森湾に生息するギボシムシ類(半索動物腸鰓綱)2011

    • Author(s)
      浦田慎、美濃川拓哉、西川輝昭、阿部広和、鷲尾正彦
    • Organizer
      日本動物学会第82回大会
    • Place of Presentation
      旭川市大雪クリスタルホール
    • Year and Date
      2011-09-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] 青森県陸奥湾で発見されたミサキギボシムシについて2011

    • Author(s)
      阿部広和、鷲尾正彦、山嵜敦子、西川輝昭、美濃川拓哉
    • Organizer
      日本動物学会平成23年度東北支部大会
    • Place of Presentation
      弘前大学農学生命科学部
    • Year and Date
      2011-07-30
    • Related Report
      2012 Final Research Report
  • [Presentation] オカメブンブクとツガルウニから探る"ウニ幼生骨片形成機構"の進化2011

    • Author(s)
      山嵜敦子、美濃川拓哉
    • Organizer
      日本動物学会平成23年度東北支部大会
    • Place of Presentation
      弘前大学農学生命科学部
    • Year and Date
      2011-07-30
    • Related Report
      2012 Final Research Report
  • [Presentation] ウニ類における第一卵割面と幼生前後軸の関係:その多様性と進化2011

    • Author(s)
      美濃川拓哉、雨宮昭南
    • Organizer
      日本動物学会平成23年度東北支部大会
    • Place of Presentation
      弘前大学農学生命科学部
    • Year and Date
      2011-07-30
    • Related Report
      2012 Final Research Report
  • [Presentation] 直接発生メカニズムの進化2010

    • Author(s)
      美濃川拓哉
    • Organizer
      水腔動物(Ambulacraria)の発生生物学
    • Place of Presentation
      東京大学三崎臨海実験所
    • Year and Date
      2010-11-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] 原始的ウニ・キダリスの間充織特異化メカニズム

    • Author(s)
      山嵜敦子
    • Organizer
      日本動物学会第83回大会
    • Place of Presentation
      大阪大学
    • Related Report
      2012 Annual Research Report
  • [Presentation] ウニ類における「小割球」の進化

    • Author(s)
      山嵜敦子
    • Organizer
      第9回棘皮動物研究集会
    • Place of Presentation
      東北大学農学部
    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      https://sites.google.com/site/minokawalab/

    • Related Report
      2012 Final Research Report
  • [Remarks]

    • URL

      https://sites.google.com/site/minokawalab/

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      https://sites.google.com/site/minokawalab/

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://researchmap.jp/takuyaminokawa/

    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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