Analysis of mechanism for neural-epidermal boundary formation
| Project/Area Number |
22570200
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Developmental biology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
MICHIUE Tatsuo 東京大学, 大学院・総合文化研究科, 准教授 (10282724)
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| Co-Investigator(Kenkyū-buntansha) |
KURODA Hiroki 静岡大学, 大学院・教育学研究科, 准教授 (70402229)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 形態形成 / 胚パターニング / ツメガエル / プラコード / 境界規定 / 神経綉導 / アフリカツメガエル / パターニング / 神経誘導 |
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| Research Abstract |
In this study, (1)We analyzed the function of PRDM12. When PRDM12 MO was injected, the expression of several placode formation was specifically inhibited. (2) We found that suitable dose of BMP/Wnt inhibitor efficiently induced placode. (3) The analysis of Xnr3 indicated that injection with Xnr3 effected on the shape of cells locatedin neural-epidermal border region, and that the expression of placode marker and brain marker was altered.
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Report
(4 results)
Research Products
(40 results)
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[Journal Article] Reduction of N-Glycolylneuraminic Acid in Human Induced Pluripotent Stem Cells Generated or Cultured under Feeder- and Serum-Free Defined Conditions2010
Author(s)
Hayashi Y, Chan T, Warashina M, Fukuda M, Ariizumi T, Okabayashi K, Takayama N, Otsu M, Eto K, Furue MK, Michiue T, OhnumaK, Nakauchi H, Asashima M
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Journal Title
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[Journal Article] Induction of neural crest cells from mouse embryonic stem cells in a serum-free monolayer culture2010
Author(s)
Aihara Y, Hayashi Y, Hirata M, Ariki N, Shibata S, Nagoshi N, Nakanishi M, Ohnuma K, Warashina M, Michiue T, Uchiyama H, Okano H, Asashima M, Furue MK
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Journal Title
Int J Dev Biol
Volume: 54
Pages: 1287-94
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[Presentation]2012
Author(s)
Nejigane S, Michiue T, Asashima M.
Organizer
14th international Xenopus conference
Place of Presentation
Hyeres, France
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[Presentation] Establishment of an efficient neural crest cell induction system from mouse embryonic stem cells in defined medium2011
Author(s)
Aihara Y, Hayashi Y, Hirata M, Ariki N, Shibata S, Nagoshi N, Nakanishi M, Ohnuma K, Warashina M, Michiue T, Uchiyama H, Okano H, Asashima M, Kusuda-Furue M.
Organizer
9th International Society for StemCell Research annual meeting
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